CAS 466-06-8

Proscillaridin

Description:

Proscillaridin, with the CAS number 466-06-8, is a cardiac glycoside derived from the plant species Scilla maritima, commonly known as sea squill. This compound exhibits a structure characterized by a steroid nucleus with a lactone ring, which is typical of cardiac glycosides. Proscillaridin is known for its ability to inhibit the Na+/K+ ATPase enzyme, leading to increased intracellular sodium and calcium concentrations, ultimately enhancing cardiac contractility. This mechanism makes it useful in the treatment of certain heart conditions, particularly heart failure and arrhythmias. The substance is also noted for its potential toxic effects, which can include gastrointestinal disturbances and cardiac arrhythmias if misused. Proscillaridin is typically administered under strict medical supervision due to its narrow therapeutic index. Additionally, it has been studied for its potential anti-inflammatory and anticancer properties, although further research is needed to fully understand these effects. Overall, proscillaridin is a significant compound in pharmacology, particularly in cardiology.

Formula: C₃₀H₄₂O₈

InChI: InChI=1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19-,20+,21-,22+,24-,25+,26+,27-,28-,29+,30-/m0/s1

InChI key: InChIKey=MYEJFUXQJGHEQK-ALRJYLEOSA-N

SMILES: O[C@@]12[C@]3([C@@]([C@]4(C)C(CC3)=C[C@@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)CC4)(CC[C@]1(C)[C@H](CC2)C=6C=CC(=O)OC6)[H])[H]

Synonyms:

• (3Beta)-3-[(6-Deoxyhexopyranosyl)Oxy]-14-Hydroxybufa-4,20,22-Trienolide
• (3Beta,8Xi,9Xi)-3-[(6-Deoxyhexopyranosyl)Oxy]-14-Hydroxybufa-4,20,22-Trienolide
• (3beta)-3-[(6-deoxy-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide
• (3beta)-3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide
• (3β)-3-[(6-Deoxy-α-<span class="text-smallcaps">L</span>-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide
• 14-Hydroxy-3β-(rhamnosyloxy)bufa-4,20,22-trienolide
• 3β-Rhamnosido-14β-hydroxy-Δ^4,20,22-bufatrienolide
• 3β-[(6-Deoxy-α-<span class="text-smallcaps">L</span>-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide
• A 32686
• Bufa-4,20,22-trienolide, 3-[(6-deoxy-α-<span class="text-smallcaps">L</span>-mannopyranosyl)oxy]-14-hydroxy-, (3β)-
• Caradrin
• Cardion
• Cardiovite
• Carmazon
• Coratol
• Desglucotransvaaline
• Desglucotrnasvaaline
• Herzo Proscillan
• NSC 7521
• Procardin
• Procilan
• Proscillan
• Proscillaridin
• Proslladin
• Prostosin
• Proszine
• Protasin
• Psc-801
• Purosin-TC
• Sandoscill
• Scillacrist
• Scillarenin 3β-rhamnoside
• Simeon
• Solestril
• Stellarid
• Talucard
• Talusin
• Tradenal
• Transvaalin, degluco-
• Urgilan
• Wirnesin
• Proscillaridin A
• Bufa-4,20,22-trienolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-14-hydroxy-, (3β)-

Proscillaridin A

CAS: 466-06-8

Proscillaridin A analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₃₀H₄₂O₈

Purity: (HPLC) ≥90%

Color and Shape: Powder

Molecular weight: 530.67

Ref: 11-0852

Proscillaridin A

CAS: 466-06-8

Proscillaridin A

Purity: ≥98%

Molecular weight: 530.65g/mol

Ref: 54-BUP21968

Proscillaridin A

CAS: 466-06-8

Formula: C₃₀H₄₂O₈

Molecular weight: 530.65

Ref: 7W-GP5422

Proscillaridin A

CAS: 466-06-8

Formula: C₃₀H₄₂O₈

Purity: 95%~99%

Molecular weight: 530.658

Ref: BP-BP1153

Proscillaridin a

CAS: 466-06-8

Digitalis glycoside

Formula: C₃₀H₄₂O₈

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 530.66

Ref: 5G-82774

Proscillaridin A

CAS: 466-06-8

Cardiac glycoside; aglycone is Scillarenin

Formula: C₃₀H₄₂O₈

Purity: Min. 95 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 530.65 g/mol

Ref: 3D-MP45299

Proscillaridin A - Bio-X ™

CAS: 466-06-8

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₃₀H₄₂O₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 530.65 g/mol

Ref: 3D-BP300151

Proscillaridin A

CAS: 466-06-8

Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.

Formula: C₃₀H₄₂O₈

Purity: 98.38%

Color and Shape: Solid

Molecular weight: 530.65

Ref: TM-TN2105

Proscillaridin A

Controlled Product

CAS: 466-06-8

Applications Proscillaridin A is a cardiac glycoside that can be used to treat congestive heart failure and cardiac arrhythmia. In addition, Proscillaridin A also inhibit breast cancer MCF-7 cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Prassas, I. and Diamandis, E. P.: Nat. Rev. Drug Discov. 7, 926 (2008); Milutinovic, S., et al.: PloS One 11, e0152692/1 (2016); Bielawski, K., et al.: ?Biol. Pharm. Bull 29, 1493 (2006)

Formula: C₃₀H₄₂O₈

Color and Shape: Neat

Molecular weight: 530.65

Ref: TR-P838495