CAS 466-24-0

Benzoylaconine

Description:

Benzoylaconine is a chemical compound classified as an alkaloid, specifically derived from the plant Aconitum, commonly known as monkshood or wolfsbane. It is characterized by its complex structure, which includes a benzoyl group attached to an aconitine skeleton. This compound exhibits notable pharmacological properties, including analgesic and anti-inflammatory effects, which have drawn interest in medicinal chemistry. However, it is also important to note that benzoylaconine, like other aconitine derivatives, can be highly toxic and poses significant risks if ingested improperly. Its mechanism of action primarily involves the modulation of ion channels, particularly sodium channels, which can lead to various physiological effects. In terms of physical properties, benzoylaconine is typically a crystalline solid, and its solubility can vary depending on the solvent used. Due to its potential toxicity and the presence of other bioactive compounds in Aconitum species, handling and usage of benzoylaconine require caution and adherence to safety protocols.

Formula: C₃₂H₄₅NO₁₀

InChI: InChI=1S/C32H45NO10/c1-6-33-14-29(15-39-2)18(34)12-19(40-3)31-17-13-30(37)26(43-28(36)16-10-8-7-9-11-16)20(17)32(38,25(35)27(30)42-5)21(24(31)33)22(41-4)23(29)31/h7-11,17-27,34-35,37-38H,6,12-15H2,1-5H3/t17-,18-,19+,20-,21+,22+,23-,24-,25+,26-,27+,29+,30-,31+,32-/m1/s1

InChI key: InChIKey=DHJXZSFKLJCHLH-BMTFSNIDSA-N

SMILES: O(C)[C@@H]1[C@@]23[C@]4([C@](COC)(CN(CC)[C@@]2([C@]([C@@H]4OC)([C@]5(O)[C@@]6([C@]3(C[C@@](O)([C@@H]6OC(=O)C7=CC=CC=C7)[C@@H](OC)[C@@H]5O)[H])[H])[H])[H])[C@H](O)C1)[H]

Synonyms:

• 11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-3,8,13,14,15-pentol deriv.
• 14-Benzoylaconine
• 14-O-Benzoylaconine
• Aconine 14-benzoate
• Aconitane-3,8,13,14,15-Pentol, 20-Ethyl-1,6,16-Trimethoxy-4-(Methoxymethyl)-, 14-Benzoate, (1Alpha,3Alpha,6Alpha,14Alpha,15Alpha,16Beta)-
• Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 14-benzoate, (1α,3α,6α,14α,15α,16β)-
• Benzaconine
• Benzoylaconine
• Isaconitine
• Picraconitine
• Pikraconitin

14-Benzoylaconine

CAS: 466-24-0

Benzoylaconine and aconitine can induce reproductive toxicity in BeWo Cell, the amino acid metabolism was the main metabolic pathway and responsible for the placental and fetal toxicity of them.

Formula: C₃₂H₄₅NO₁₀

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 603.709

Ref: BP-BP0024

Benzoylaconine

CAS: 466-24-0

Benzoylaconine, an alkaloid in Fuzi, with aconitine causes reproductive toxicity via amino acid metabolism.

Formula: C₃₂H₄₅NO₁₀

Purity: 99.44% - 99.861%

Color and Shape: Solid

Molecular weight: 603.7

Ref: TM-T6S1880

Benzoylaconine

CAS: 466-24-0

Benzoylaconine

Purity: ≥98%

Molecular weight: 603.7g/mol

Ref: 54-BUP03361

Benzoylaconine

Controlled Product

CAS: 466-24-0

Applications Benzoylaconine is a diterpenoid alkaloid that was discovered as antidote to aconitine-type neurotoxin poisoning. References Tursunkhodzhaeva, F., et al.: Chem. Nat. Compd., 52, 849 (2016)

Formula: C₃₂H₄₅NO₁₀

Color and Shape: Neat

Molecular weight: 603.7

Ref: TR-B207760

14-Benzoylaconine

CAS: 466-24-0

Formula: C₃₂H₄₅NO₁₀

Molecular weight: 603.71

Ref: 7W-GY5306

Benzoylaconine

CAS: 466-24-0

Benzoylaconine is a naturally occurring secondary metabolite, which is derived from the roots and other parts of plants belonging to the Aconitum genus. This compound is a type of diterpenoid alkaloid, which is primarily sourced from the plant species known for their potent and complex alkaloid compositions. The mode of action of benzoylaconine involves interacting with voltage-gated sodium channels, modulating their function, which can result in neurotoxic effects. This compound's action on sodium channels alters nerve impulse transmission, potentially leading to severe physiological effects if not carefully controlled.

Formula: C₃₂H₄₅NO₁₀

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 603.7 g/mol

Ref: 3D-FB73893

Benzoylaconine

CAS: 466-24-0

Formula: C₃₂H₄₅NO₁₀

Purity: 99%

Color and Shape: Solid

Molecular weight: 603.7004

Ref: IN-DA00DB87