CAS 467-04-9

Oripavine

Description:

Oripavine is a semi-synthetic opioid derived from thebaine, which is an alkaloid found in opium poppy. It is characterized by its potent analgesic properties, making it relevant in the field of pain management. Oripavine exhibits a high affinity for opioid receptors, particularly the mu-opioid receptor, which is primarily responsible for its pain-relieving effects. Its chemical structure includes a phenanthrene core, typical of many opioids, and it possesses various functional groups that contribute to its pharmacological activity. Oripavine is known for its lower potential for abuse compared to other opioids, which makes it a subject of interest in developing safer analgesics. Additionally, it has been studied for its potential in treating opioid dependence and withdrawal symptoms. However, like other opioids, it can still lead to side effects such as sedation, respiratory depression, and constipation. Due to its controlled status, research and usage of Oripavine are regulated in many countries.

Formula: C₁₈H₁₉NO₃

InChI: InChI=1S/C18H19NO3/c1-19-8-7-18-11-4-6-14(21-2)17(18)22-16-13(20)5-3-10(15(16)18)9-12(11)19/h3-6,12,17,20H,7-9H2,1-2H3/t12-,17+,18+/m1/s1

InChI key: InChIKey=ZKLXUUYLEHCAMF-UUWFMWQGSA-N

SMILES: O(C)C=1[C@]2([C@]34C=5C(O2)=C(O)C=CC5C[C@](C3=CC1)(N(C)CC4)[H])[H]

Synonyms:

• (5Alpha)-6-Methoxy-17-Methyl-6,7,8,14-Tetradehydro-4,5-Epoxymorphinan-3-Ol
• (5alpha)-6,7,8,14-Tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol
• (5α)-6,7,8,14-Tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol
• 6,7,8,14-Tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-morphinan-3-ol
• Brn 0046094
• DEA No. 9330
• Morphinan-3-ol, 6,7,8,14-tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-
• Morphinan-3-ol, 6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methyl-, (5α)-
• Morphinan-3-ol, 6,7,8,14-tetradehydro-4,5α-epoxy-6-methoxy-17-methyl-
• 4-27-00-02270 (Beilstein Handbook Reference)
• Oripavine

Oripavine 0.1 mg/ml in Methanol

Controlled Product

CAS: 467-04-9

Color and Shape: Single Solution

Ref: 61-AMP0037.13-02

Oripavine

Controlled Product

CAS: 467-04-9

Color and Shape: Neat

Ref: 61-FOR0037.13

Oripavine

Controlled Product

CAS: 467-04-9

Formula: C18 H19 N O3

Color and Shape: off-white solid

Molecular weight: 297.35

Ref: 61-LGCFOR0037.13

6,7,8,14-Tetradehydro-4,5α-epoxy-6-methoxy-17-methylmorphinan-3-ol (Oripavine)

Controlled Product

CAS: 467-04-9

Formula: C₁₈H₁₉NO₃

Color and Shape: Neat

Molecular weight: 297.35

Ref: 86-MM0037.13

Oripavine

Controlled Product

CAS: 467-04-9

Applications The major metabolite of Thebaine. Oripavine possesses an analgesic potency comparable to Morphine; it is not clinically useful due to severe toxicity and low therapeutic index. An opiate.
References Barber, R., et al.: J. Med. Chem., 18, 1074 (1975), Yamazoe, Y., et al.: J. Pharmacol., 31, 433 (1981),

Formula: C₁₈H₁₉NO₃

Color and Shape: Off-White

Molecular weight: 297.35

Ref: TR-O675000

Oripavine

Controlled Product

CAS: 467-04-9

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Formula: C₁₈H₁₉NO₃

Purity: (%) Reported (%)

Molecular weight: 297.35 g/mol

Ref: 3D-O-0050