CAS 467214-20-6

17-Dimethylaminoethylamino-17-demethoxygeldanamycin

Description:

17-Dimethylaminoethylamino-17-demethoxygeldanamycin, commonly referred to as 17-DMAG, is a synthetic derivative of geldanamycin, a natural product known for its ability to inhibit heat shock protein 90 (Hsp90). This compound is characterized by its structural modifications that enhance its solubility and bioavailability compared to its parent compound. 17-DMAG exhibits potent antitumor activity, particularly in various cancer cell lines, by disrupting the chaperone function of Hsp90, leading to the degradation of client oncoproteins. Its mechanism of action involves the induction of apoptosis and inhibition of cell proliferation. The compound is typically administered in a clinical setting for cancer treatment and is under investigation for its efficacy in combination therapies. Additionally, 17-DMAG's pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for determining its therapeutic potential and safety profile. As with many chemotherapeutic agents, monitoring for side effects and interactions with other medications is essential during treatment.

Formula: C₃₂H₄₈N₄O₈

InChI: InChI=1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1

InChI key: InChIKey=KUFRQPKVAWMTJO-LMZWQJSESA-N

SMILES: N(CCN(C)C)C1=C2C(=O)C(=CC1=O)NC(=O)/C(/C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)\C(\C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2

Synonyms:

• 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
• 17-Dimethylaminoethylamino-17-demethoxygeldanamycin
• 17-Dmag
• 17-N-(2-Dimethylaminoethylamino)-17-demethoxygeldanamycin
• 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin
• Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-
• NSC 707545
• AlvespiMycin(17-DMAG)
• 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin Hydrochloride
• 17-DMAGhydrochloride
• 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride
• 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin
• DMAG Hydrochloride
• DMAG-d6
• 17-DMAG;KOS-1022;NSC-707545
• Unii-001L2fe0m3
• 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxygeldanaMycin Hydrochloride
• 17-DMAG (Alvespimycin)
• 17DMAG (17-diMethylaMinoethylaMino-17-deMethoxy-geldanaMycin)
• 17-[2-(DiMethylaMino)ethylaMino]-17-desMethylgeldanaMycin Hydrochloride
• 17-DeMethoxy-17-[[2-[(diMethyl-d6)aMino]ethyl]aMino]geldanaMycin
• 17-DMAG-d6
• NSC 707545 Hydrochloride
• 17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG
• 17-DMAG/ Alvespimycin/ 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
• AlvespiMycin-d6
• 17-[2-[(DiMethyl-d6)aMino]ethylaMino]-17-desMethylgeldanaMycin
• 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin-d6
• (150270-08-9) alvespimycin
• Alvespimycin
• In-house Standard
• NSC 707545-d6
• CS-2382
• AlvespiMycin freebase

17-DMAG

CAS: 467214-20-6

Formula: C₃₂H₄₈N₄O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 616.7455

Ref: IN-DA007217

Alvespimycin

CAS: 467214-20-6

Alvespimycin

Purity: ≥98%

Molecular weight: 616.75g/mol

Ref: 54-BUP06560

17-Dimethylaminoethylamino-17-demethoxygeldanamycin

CAS: 467214-20-6

17-Dimethylaminoethylamino-17-demethoxygeldanamycin

Color and Shape: Purple Powder

Molecular weight: 653.21g/mol

Ref: 54-BID1002

17-Dimethylaminoethylamino-17-demethoxygeldanamycin

CAS: 467214-20-6

Formula: C₃₂H₄₈N₄O₈

Purity: ≥ 98.0%

Color and Shape: Purple to black powder

Molecular weight: 616.75

Ref: 7W-GA4123

Alvespimycin Hydrochloride

CAS: 467214-20-6

Formula: C₃₂H₄₈N₄O₈·HCl

Molecular weight: 616.76 36.46

Ref: 4Z-A-368001

Alvespimycin

CAS: 467214-20-6

Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.

Formula: C₃₂H₄₈N₄O₈

Purity: 99.88%

Color and Shape: Solid

Molecular weight: 616.75

Ref: TM-T20890

Alvespimycin hydrochloride

CAS: 467214-20-6

Alvespimycin hydrochloride is a chemical inhibitor that binds and inhibits the ATP-binding site of Hsp90, an enzyme involved in protein synthesis. This inhibition prevents the release of other proteins that are needed for protein synthesis, leading to cell death. Alvespimycin hydrochloride has been shown to have anti-cancer properties in vitro assays. Alvespimycin hydrochloride is a semi-synthetic derivative of the antibiotic geldanamycin

Formula: C₃₂H₄₈N₄O₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 616.75 g/mol

Ref: 3D-AA43412

17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin-d6

Controlled Product

CAS: 467214-20-6

Formula: C₃₂D₆H₄₂N₄O₈

Color and Shape: Neat

Molecular weight: 622.783

Ref: TR-D470932