CAS 467214-21-7
:Alvespimycin
Description:
Alvespimycin, with the CAS number 467214-21-7, is a synthetic compound that belongs to the class of antibiotics known as ansamycins. It is primarily recognized for its potential as an antitumor agent, exhibiting activity against various cancer cell lines. Alvespimycin functions by inhibiting the heat shock protein 90 (Hsp90), a molecular chaperone that plays a crucial role in the proper folding and functioning of numerous client proteins involved in cell signaling and survival. By disrupting Hsp90 activity, Alvespimycin can lead to the degradation of oncogenic proteins, thereby inducing apoptosis in cancer cells. The compound has been studied for its efficacy in treating different types of malignancies, including those resistant to conventional therapies. Additionally, Alvespimycin's structure features a complex bicyclic core, contributing to its biological activity. Its pharmacokinetics, toxicity profile, and therapeutic potential continue to be subjects of research, aiming to optimize its use in clinical settings.
Formula:C32H48N4O8
Synonyms:- 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin
- 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
- 17-Dmag
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Found 7 products.
Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-,monohydrochloride
CAS:Formula:C32H49ClN4O8Purity:%Color and Shape:SolidMolecular weight:653.206517-Dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride
CAS:<p>17-Dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride</p>Purity:98%Molecular weight:653.21g/molAlvespimycin hydrochloride
CAS:Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.Formula:C32H48N4O8·HClPurity:99.94%Color and Shape:SolidMolecular weight:653.2117-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride
CAS:<p>Applications 17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.<br>References Dote, H. et al.: Cancer Res., 66, 9211 (2006); Smith, V. et al.: Cancer Chemother. Pharmacol., 56, 126 (2005); Egorin, M.J. et al.: Cancer Chemother. Pharmacol., 49, 7 (2002);<br></p>Formula:C32H49ClN4O8Color and Shape:NeatMolecular weight:653.2117-DMAG hydrochloride
CAS:<p>Heat shock protein 90 (HSP90) inhibitor</p>Formula:C32H48N4O8·HClPurity:Min. 95%Color and Shape:SolidMolecular weight:653.21 g/mol
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