CAS 4673-26-1

Diphenyleneiodonium chloride

Description:

Diphenyleneiodonium chloride (DPI) is an organoiodine compound characterized by its unique structure, which features a central iodine atom bonded to two phenyl groups and a chloride ion. It is typically encountered as a yellow to orange crystalline solid. DPI is known for its role as a potent inhibitor of various biological processes, particularly in the context of redox reactions, where it acts as an electron acceptor. This compound is often utilized in biochemical research to study oxidative stress and cellular signaling pathways. Its reactivity is attributed to the presence of the iodine atom, which can participate in various chemical reactions, including those involving nucleophiles. Additionally, DPI is soluble in organic solvents but has limited solubility in water. Safety precautions should be taken when handling this compound, as it can be toxic and irritant. Overall, Diphenyleneiodonium chloride serves as a valuable tool in both chemical and biological research, providing insights into the mechanisms of oxidative damage and cellular responses.

Formula: C₁₂H₈I·Cl

InChI: InChI=1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1

InChI key: InChIKey=FCFZKAVCDNTYID-UHFFFAOYSA-M

SMILES: C1=2C=3C([I+]C1=CC=CC2)=CC=CC3.[Cl-]

Synonyms:

• Diphenyleneiodonium chloride
• Dibenziodolium chloride
• Dibenziodolium, chloride (1:1)
• Dibenziodolium, chloride

Diphenyleneiodonium chloride

CAS: 4673-26-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₂H₈I·Cl

Molecular weight: 314.55

Ref: 02-J64838

DIPHENYLENEIODONIUM CHLORIDE

CAS: 4673-26-1

Formula: C₁₂H₈ClI

Purity: 97%

Color and Shape: Solid

Molecular weight: 314.5494

Ref: IN-DA00366I

Diphenyleneiodonium chloride

CAS: 4673-26-1

Diphenyleneiodonium chloride

Purity: ≥95%

Molecular weight: 314.55g/mol

Ref: 54-BUP06392

Diphenyleneiodonium Chloride

CAS: 4673-26-1

Diphenyleneiodonium Chloride

Purity: 99%

Molecular weight: 314.55g/mol

Ref: 54-OR1012987

Diphenyleneiodonium chloride

CAS: 4673-26-1

Formula: C₁₂H₈ClI

Purity: ≥ 95%

Color and Shape: White or off-white powder

Molecular weight: 314.55

Ref: 7W-GL1975

Dibenzo[b,d]iodol-5-ium Chloride

CAS: 4673-26-1

Formula: C₁₂H₈ClI

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 314.55

Ref: 3B-D6364

Diphenyleneiodonium chloride

CAS: 4673-26-1

Diphenyleneiodonium chloride (DPI) inhibits iNOS & eNOS (IC50: 50 nM & 0.3 μM) and has wide-ranging bactericidal properties.

Formula: C₁₂H₈ClI

Purity: 99.71% - 99.86%

Color and Shape: Solid

Molecular weight: 314.55

Ref: TM-T7191

Diphenyleneiodonium Chloride

Controlled Product

CAS: 4673-26-1

Applications Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase.Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90
References Jones, et al.: Biochem J., 265, 95 (1990), Stuehr, et al.: FASEB J., 5, 98 (1991), Wang, Y-X, et al.: J. of Pharmacology & Exp. Therap., 265, 1 , 263 (1993) Circulation Research, 74 (6), 1142 (1994), Cruz, T.F., et al.: J.B.C., 271, 26, 15703(1996)

Formula: C₁₂H₈I·Cl

Color and Shape: Neat

Molecular weight: 314.55

Ref: TR-D491500

Diphenyleneiodonium chloride

CAS: 4673-26-1

Diphenyleneiodonium chloride is a diphenyliodonium salt that inhibits neuronal death and induces pluripotent stem cells. It has been shown to activate toll-like receptor 4 (TLR4) which initiates the inflammatory response, leading to the activation of growth factor-β1 and polymerase chain reactions. This compound also has an oral hypoglycemic effect and can be used as an antidiabetic drug. Diphenyleneiodonium chloride has also been shown to induce oxidative cell death in cancer cells by inhibiting the production of NADPH oxidase, which is required for caspase-independent cell death.

Formula: C₁₂H₈ClI

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 314.55 g/mol

Ref: 3D-FD22495

DIPHENYLENEIODONIUM CHLORIDE

CAS: 4673-26-1

Purity: 97%

Molecular weight: 314.5499878

Ref: 10-F801858