CAS 4682-50-2

Trichodermin

Description:

Trichodermin is a natural compound classified as a trichothecene mycotoxin, primarily produced by certain species of fungi, particularly Trichoderma. It is known for its antifungal properties and is often studied for its potential applications in agriculture as a biopesticide. Trichodermin exhibits a complex molecular structure, which contributes to its biological activity, including the inhibition of fungal growth and the modulation of plant defense mechanisms. The compound is characterized by its ability to disrupt protein synthesis in sensitive organisms, making it effective against a range of phytopathogenic fungi. Additionally, Trichodermin has been investigated for its potential use in medicine, particularly in the context of its cytotoxic effects on certain cancer cell lines. However, its use is regulated due to its toxicological profile, which necessitates careful handling and application. Overall, Trichodermin represents a significant area of research in both agricultural and pharmaceutical fields, highlighting the importance of natural products in developing sustainable solutions for pest management and disease treatment.

Formula: C₁₇H₂₄O₄

InChI: InChI=1/C17H24O4/c1-10-5-6-15(3)12(7-10)21-14-8-13(20-11(2)18)16(15,4)17(14)9-19-17/h7,12-14H,5-6,8-9H2,1-4H3/t12-,13-,14-,15+,16-,17-/m1/s1

InChI key: InChIKey=HNEGCRMUYSKRRR-IKIFYQGPSA-N

SMILES: C[C@@]12[C@@]3([C@@](C[C@H]1OC(C)=O)(O[C@]4([C@]2(C)CCC(C)=C4)[H])[H])CO3

Synonyms:

• 12,13-Epoxytrichothec-9-en-4β-ol acetate
• Trichothec-9-en-4-ol, 12,13-epoxy-, acetate, (4β)-
• Trichothec-9-en-4β-ol, 12,13-epoxy-, acetate
• Trichodermin
• WG 696
• Spiro[2,5-methano-1-benzoxepin-10,2′-oxirane], trichothec-9-en-4-ol deriv.
• B-4-0-acetate -12,13-epoxytrichothec-9-en-4-ol
• Trichoderonin

Trichodermin

CAS: 4682-50-2

Trichodermin is a naturally occurring sesquiterpene antibiotic (antibiotic) and a powerful inhibitor of protein synthesis (protein synthesis). It binds to eukaryotic ribosomes, inhibiting protein translation by interacting with peptidyl transferase. Trichodermin suppresses oral cancer growth by inducing apoptosis (apoptosis)-related mitochondrial dysfunction and HDAC-2-mediated signaling. It exhibits potent antimicrobial activity against filamentous fungi, yeasts, and bacteria.

Formula: C₁₇H₂₄O₄

Color and Shape: Solid

Molecular weight: 292.37

Ref: TM-TN10949