CAS 468740-43-4

4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-(4-methyl-6-morpholin-4-yl-1H-benzimidazol-2-yl)pyridin-2(1H)-one

Description:

The chemical substance known as 4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-(4-methyl-6-morpholin-4-yl-1H-benzimidazol-2-yl)pyridin-2(1H)-one, with the CAS number 468740-43-4, is a complex organic compound characterized by its multi-functional structure. It features a pyridinone core, which is a bicyclic compound containing a pyridine ring fused to a lactam. The presence of a benzimidazole moiety contributes to its potential biological activity, while the morpholine and chlorophenyl groups enhance its solubility and interaction with biological targets. The compound is likely to exhibit properties such as moderate to high lipophilicity due to the aromatic and aliphatic components, which may influence its pharmacokinetics. Additionally, the hydroxyl and amino functional groups suggest potential for hydrogen bonding, which can affect its binding affinity to biological receptors. Overall, this compound may be of interest in medicinal chemistry, particularly in the development of therapeutic agents targeting specific diseases.

Formula: C₂₅H₂₆ClN₅O₃

InChI: InChI=1/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1

SMILES: Cc1cc(cc2c1[nH]c(c1c(ccnc1O)NC[C@H](c1cccc(c1)Cl)O)n2)N1CCOCC1

Synonyms:

• Bms-536924

Insulin-like Growth Factor-1 Receptor Inhibitor

CAS: 468740-43-4

Formula: C₂₅H₂₆ClN₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 479.9586

Ref: IN-DA00DB57

BMS-536924

CAS: 468740-43-4

BMS-536924

Purity: ≥98%

Molecular weight: 479.96g/mol

Ref: 54-BUP05122

BMS-536924

CAS: 468740-43-4

BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for

Formula: C₂₅H₂₆ClN₅O₃

Purity: 99.02%

Color and Shape: Solid

Molecular weight: 479.96

Ref: TM-T6419

(S)-4-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one

CAS: 468740-43-4

Purity: 98.0%

Molecular weight: 479.172417372

Ref: 10-F549641

BMS 536924

CAS: 468740-43-4

BMS 536924 is a novel small molecule that is an ATP-binding cassette transporter (ABC) inhibitor. It has been shown to inhibit the ABCB1, ABCC1 and ABCG2 transporters in vitro. BMS 536924 has also been shown to increase cytosolic calcium levels in prostate cancer cells. This drug was found to induce apoptosis in insulin-stimulated glucose-6-phosphatase (IGP)-deficient mouse fibroblasts, which may be due to its ability to inhibit IGF-I production.

Formula: C₂₅H₂₆ClN₅O₃

Purity: Min. 95%

Molecular weight: 479.96 g/mol

Ref: 3D-TTA74043