CAS 469-59-0

Jervine

Description:

Jervine is a naturally occurring alkaloid primarily found in certain plant species, particularly in the family of plants known as the Liliaceae. It is classified as a steroidal alkaloid and is structurally related to other compounds such as veratramine and cyclopamine. Jervine is characterized by its complex steroid structure, which contributes to its biological activity. It exhibits a range of pharmacological effects, including potential neurotoxic properties, and has been studied for its impact on various physiological processes. The compound is known to interact with specific receptors in the nervous system, which can lead to both therapeutic and toxicological implications. Due to its biological activity, jervine has garnered interest in medicinal chemistry and pharmacology, although its use is limited due to safety concerns. As with many alkaloids, handling jervine requires caution due to its potential toxicity and the need for further research to fully understand its effects and applications.

Formula: C₂₇H₃₉NO₃

InChI: InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1

InChI key: InChIKey=CLEXYFLHGFJONT-DNMILWOZSA-N

SMILES: CC=1[C@@]2(O[C@]3([C@]([C@H]2C)(NC[C@@H](C)C3)[H])[H])CC[C@@]4(C1C(=O)[C@]5([C@]4(CC=C6[C@]5(C)CC[C@H](O)C6)[H])[H])[H]

Synonyms:

• (2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-Hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one
• (3beta,22S,23R)-3-hydroxy-17,23-epoxyveratraman-11-one
• 17,23beta-Epoxy-3beta-hydroxyveratraman-11-one
• Brn 0059109
• Hsdb 3502
• Iervin
• Jervin
• Jerwiny
• Nsc 23898
• Nsc 7520
• Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)-pyridin)-11(1H)-one, 2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy- 3',6',10,11b-tetramethyl-
• Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)-pyridin)-11(1H)-one, 2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10, 11B-tetramethyl-
• Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethyl-, (2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-
• Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethyl-, [3S-(3α,6aα,6bβ,9α(3′S*,3′aR*,6′R*,7′aS*),11aβ,11bα)]-
• Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3-beta,23-beta)-
• Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3beta,23beta)-
• Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-

JERVINE

CAS: 469-59-0

Formula: C₂₇H₃₉NO₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 425.6035

Ref: IN-DA00D9RK

Jervine

CAS: 469-59-0

Jervine

Purity: ≥98%

Molecular weight: 425.6g/mol

Ref: 54-BUP10771

Jervine

CAS: 469-59-0

Jervine

Purity: 98%

Molecular weight: 425.6g/mol

Ref: 54-OR1026163

Jervine

CAS: 469-59-0

Formula: C₂₇H₃₉NO₃

Purity: >97.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 425.61

Ref: 3B-J0009

Jervine

CAS: 469-59-0

Jervine exhibits cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249, it induces COX-2 overexpression in human erythroleukemia cells. Jervine exhibits potent toxic effects against Colorado potato beetle.

Formula: C₂₇H₃₉NO₃

Purity: 95%~99%

Molecular weight: 425.613

Ref: BP-BP0810

Jervine

CAS: 469-59-0

Formula: C₂₇H₃₉NO₃

Purity: ≥ 98.0%

Color and Shape: White or off-white powder

Molecular weight: 425.60

Ref: 7W-GL5097

Jervine

CAS: 469-59-0

Jervine inhibits Smoothened, blocking Hedgehog signaling and GLI1 transcription activation.

Formula: C₂₇H₃₉NO₃

Purity: 99.20% - 99.86%

Color and Shape: Needles From Methanol + Water Solid

Molecular weight: 425.6

Ref: TM-T3363

Jervine

CAS: 469-59-0

Natural alkaloid

Formula: C₂₇H₃₉NO₃

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 425.61

Ref: 5G-83515

Jervine

CAS: 469-59-0

Formula: C₂₇H₃₉NO₃

Color and Shape: Neat

Molecular weight: 425.60

Ref: TR-J211000

Jervine

CAS: 469-59-0

Jervine is a steroidal alkaloid, which is a naturally occurring compound derived from plants such as Veratrum californicum, commonly known as the corn lily. It possesses a unique mode of action by interfering with the Hedgehog (Hh) signaling pathway, which is crucial for regulating embryonic development and maintaining adult stem cells. Jervine achieves this by inhibiting the activity of the Smoothened (SMO) protein, a pivotal component of the Hh pathway, ultimately leading to the suppression of downstream signaling.

Formula: C₂₇H₃₉NO₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 425.6 g/mol

Ref: 3D-FJ24747

Jervine

CAS: 469-59-0

M02030 - Jervine

Formula: C₂₇H₃₉NO₃

Purity: ≥97%(HPLC)

Color and Shape: Solid

Molecular weight: 425.613

Ref: 10-M02030