CAS 469-83-0
:Cafestol
Description:
Cafestol is a natural compound primarily found in coffee, particularly in unfiltered coffee brews. It is a diterpene, specifically a type of labdane, and is known for its lipid-like structure. Cafestol is recognized for its potential health effects, including its ability to raise cholesterol levels in the blood, which has been a subject of research regarding coffee consumption and cardiovascular health. The compound is also noted for its antioxidant properties, contributing to the overall health benefits associated with coffee. Cafestol is soluble in organic solvents but has limited solubility in water, which is typical for many lipophilic compounds. Its presence in coffee varies significantly depending on the brewing method; for instance, methods like French press or Turkish coffee retain more cafestol compared to filtered coffee. Understanding the characteristics of cafestol is essential for evaluating its impact on health and nutrition, as well as its role in the complex chemistry of coffee.
Formula:C20H28O3
InChI:InChI=1/C20H28O3/c1-18-7-5-16-14(6-9-23-16)15(18)4-8-19-10-13(2-3-17(18)19)20(22,11-19)12-21/h6,9,13,15,17,21-22H,2-5,7-8,10-12H2,1H3/t13?,15-,17+,18-,19+,20+/m1/s1
InChI key:InChIKey=DNJVYWXIDISQRD-HWUKTEKMSA-N
SMILES:C[C@]12[C@]3([C@]4(C[C@]([C@](CO)(O)C4)(CC3)[H])CC[C@@]1(C5=C(CC2)OC=C5)[H])[H]
Synonyms:- (3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
- (3bS,5aS,7R,8R,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol
- (3bS,5aS,7R,8S,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol
- 5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, (3bS,5aS,7R,8R,10aR,10bS)-
- 5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, (3bS-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta))-
- 5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, [3bS-(3bα,5aβ,7β,8β,10aα,10bβ)]-
- Cafesterol
- Ccris 1518
- Cafestol
- 3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7α-methanol
- Cafestol (>85%)
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Found 10 products.
Cafestol
CAS:<p>Natural extract from coffee beans which induces glutathione S-transferase</p>Formula:C20H28O3Color and Shape:White to off white, PowderMolecular weight:316.44Cafestol
CAS:Formula:C20H28O3Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:316.44Cafestol
CAS:Cafestol has anticarcinogenic, peripheral antinociceptive and anti-inflammatory activities, it inhibits Cyclic-Strain-induced interleukin-8, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 production in vascular endothelial cells. Cafestol is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Cafestol acts as an agonist ligand for both FXR and PXR, and this may contribute to its impact on cholesterol homeostasis. Cafestol has protective effects against the CCl(4)-induced hepatotoxicity, which possibly involve mechanisms related to its ability to block the CYP2E1-mediated CCl(4) bioactivation and free radical scavenging effects. Cafestol has antidiabetic activity, it increases glucose-stimulated insulin secretion in vitro and increases glucose uptake in human skeletal muscle cells. Cafestol also has a weak inhibitory effect on osteoclastogenesis and promotes osteoblast differentiation.Formula:C20H28O3Purity:95%~99%Molecular weight:316.441CAFESTOL
CAS:<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Formula:C20H28O3Purity:97.06% - 99.08%Color and Shape:SolidMolecular weight:316.43Cafestol
CAS:Oxygen-heterocyclic compoundFormula:C20H28O3Purity:≥ 98.0 % (HPLC)Color and Shape:PowderMolecular weight:316.44Cafestol (>85%)
CAS:Controlled Product<p>Applications Cafestol is a diterpene molecule that displays anti-carcinogenic properties in studies.<br>References Higgins, L.G. et al.: Tox. App. Pharma., 226, 328 (2008); Schilter, B. et al.: Carcinogenesis, 17, 2377 (1996);<br></p>Formula:C20H28O3Purity:>85%Color and Shape:NeatMolecular weight:316.43Cafestol
CAS:<p>Cafestol is a diterpene compound, which is primarily sourced from coffee beans. It is found in the oily fraction of coffee, particularly in unfiltered types like French press and Turkish coffee. Its mode of action involves influencing lipid metabolism in the liver. Specifically, cafestol acts as an agonist for certain nuclear receptors, including FXR and PXR, which play a role in bile acid regulation and lipid homeostasis.Cafestol is known to have a notable impact on cholesterol levels. It causes an increase in serum cholesterol by reducing the excretion of bile acids, consequently enhancing cholesterol reabsorption. Due to its pronounced effects on cholesterol metabolism, cafestol is a compound of interest in cardiovascular research, especially in the context of dietary factors influencing heart health. Scientists are exploring its broader implications on lipid-related diseases and how modifying coffee preparation methods can mitigate its impact on health.</p>Formula:C20H28O3Purity:Min. 95%Color and Shape:PowderMolecular weight:316.43 g/mol
