CAS 4697-66-9

Paynantheine

Description:

Paynantheine is a naturally occurring alkaloid primarily derived from the plant species *Paynanta*, which belongs to the family of Apocynaceae. It is characterized by its complex molecular structure, which includes multiple rings and functional groups that contribute to its biological activity. The compound is known for its potential pharmacological properties, including effects on the central nervous system and possible applications in medicinal chemistry. Paynantheine exhibits solubility in organic solvents, which is typical for many alkaloids, and it may show varying degrees of stability under different environmental conditions. Its chemical behavior can be influenced by factors such as pH and temperature, which are important considerations in both laboratory and industrial settings. As with many alkaloids, paynantheine's interactions with biological systems are of significant interest, prompting research into its mechanisms of action and potential therapeutic uses. However, detailed studies on its toxicity and safety profile are essential for understanding its applicability in medicine.

Formula: C₂₃H₂₈N₂O₄

InChI: InChI=1S/C23H28N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h5-8,13-14,16,19,24H,1,9-12H2,2-4H3/b17-13+/t14-,16-,19-/m0/s1

InChI key: InChIKey=JGZKIGWXPPFMRG-CYSPOEIOSA-N

SMILES: O(C)C1=C2C3=C([C@]4(N(CC3)C[C@H](C=C)[C@@H](\C(\C(OC)=O)=C/OC)C4)[H])NC2=CC=C1

Synonyms:

• 17,18-Secoyohimban-16-carboxylic acid, 16,17,18,19-tetradehydro-9,17-dimethoxy-, methyl ester, (E)-
• Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethenyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)-, methyl ester, (αE,2S,3R,12bS)-
• Indolo[2,3-a]quinolizine, corynan-16-carboxylic acid deriv.
• Corynan-16-carboxylic acid, 16,17,18,19-tetradehydro-9,17-dimethoxy-, methyl ester, (16E)-
• Paynantheine
• Indolo(2,3-a)quinolizine-2-acetic acid, 3-ethenyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-alpha-(methoxymethylene)-, methyl ester (alphaE,2S,3R,12bS)-

Paynantheine

CAS: 4697-66-9

Paynantheine is an alkaloid with antinociceptive properties, found in Mitragyna speciosa. It also acts as an agonist at 5-HT1AR and 5-HT2BR receptors, inducing lower lip contraction and providing antinociception in rats.

Formula: C₂₃H₂₈N₂O₄

Color and Shape: Solid

Molecular weight: 396.48

Ref: TM-T203202

Paynantheine

CAS: 4697-66-9

Formula: C₂₃H₂₈N₂O₄

Molecular weight: 396.49

Ref: 4Z-P-423001

Paynantheine

CAS: 4697-66-9

Paynantheine is a naturally occurring alkaloid, which is found in the leaves of the Mitragyna speciosa plant, commonly known as kratom. This plant is native to Southeast Asia and has a long history of traditional medicinal use. Paynantheine acts as a partial agonist on mu-opioid receptors in the central nervous system, albeit with less efficacy compared to other alkaloids like mitragynine and 7-hydroxymitragynine. This molecular interaction may contribute to its potential analgesic properties, although its precise pharmacological role is less understood and remains a subject of ongoing research.

Formula: C₂₃H₂₈N₂O₄

Purity: Min 90%

Color and Shape: Powder

Molecular weight: 396.5 g/mol

Ref: 3D-EAA69766