CAS 470-42-8

Marinobufagenin

Description:

Marinobufagenin is a naturally occurring steroidal compound classified as a bufadienolide, primarily derived from the skin secretions of certain toads, particularly the marine toad. It is known for its structural similarity to other cardiac glycosides, which are compounds that can influence heart function. Marinobufagenin exhibits potent biological activity, particularly in modulating sodium and potassium ion transport across cell membranes, which can affect cardiovascular dynamics. It has been studied for its potential role in various physiological and pathological processes, including its involvement in hypertension and heart failure. The compound is characterized by its ability to inhibit the Na+/K+ ATPase enzyme, leading to increased intracellular sodium levels and subsequent effects on calcium handling in cardiac cells. Additionally, marinobufagenin has been investigated for its potential therapeutic applications, although its use is limited due to toxicity concerns associated with similar compounds. Overall, marinobufagenin represents an intriguing area of research in pharmacology and toxicology, highlighting the complex interactions between natural compounds and biological systems.

Formula: C₂₄H₃₂O₅

InChI: InChI=1S/C24H32O5/c1-21-8-5-15(25)12-23(21,27)10-7-17-16(21)6-9-22(2)18(11-19-24(17,22)29-19)14-3-4-20(26)28-13-14/h3-4,13,15-19,25,27H,5-12H2,1-2H3/t15-,16-,17+,18+,19+,21+,22+,23-,24+/m0/s1

InChI key: InChIKey=JMNQTHQLNRILMH-OBBGIPBRSA-N

SMILES: C[C@]12[C@]3([C@](O3)(C[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@@]([C@]6(C)[C@](O)(CC5)C[C@@H](O)CC6)(CC2)[H])[H]

Synonyms:

• (3β,5β,15β)-14,15-Epoxy-3,5-dihydroxybufa-20,22-dienolide
• 14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.
• 5.beta.-Bufa-20,22-dienolide, 14,15.beta.-epoxy-3.beta.,5-dihydroxy-
• 5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,5-dihydroxy-
• Bufa-20,22-Dienolide, 14,15-Epoxy-3,5-Dihydroxy-, (3Beta,5Beta,15Beta)-
• Bufa-20,22-dienolide, 14,15-epoxy-3,5-dihydroxy-, (3.beta.,5.beta.,15.beta.)-
• Bufa-20,22-dienolide, 14,15-epoxy-3,5-dihydroxy-, (3β,5β,15β)-
• Marinobufagenin
• Marinobufagin
• Marinobufogenin
• NSC 234205

Marinobufagin

CAS: 470-42-8

Formula: C₂₄H₃₂O₅

Molecular weight: 400.52

Ref: 7W-GY7758

Marinobufogenin

CAS: 470-42-8

Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure.

Formula: C₂₄H₃₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 400.51

Ref: TM-TN1912

Marinobufagin

CAS: 470-42-8

Formula: C₂₄H₃₂O₅

Purity: 95%~99%

Molecular weight: 400.515

Ref: BP-BP3644

Marinobufagin

Controlled Product

CAS: 470-42-8

Formula: C₂₄H₃₂O₅

Color and Shape: Neat

Molecular weight: 400.508

Ref: TR-M197245

Marinobufagenin

CAS: 470-42-8

Marinobufagenin is a bufadienolide compound, which is isolated from the skin and parotid glands of toads, primarily those belonging to the Bufo genus. This compound is characterized by its ability to inhibit Na⁺/K⁺-ATPase, an enzyme crucial for maintaining the electrochemical gradients of sodium and potassium ions across the cell membrane. By inhibiting this enzyme, Marinobufagenin disrupts ion homeostasis, which can lead to increased intracellular calcium concentrations in cardiac muscle cells. This action enhances the force of cardiac contraction, conferring potent cardiotonic effects.

Formula: C₂₄H₃₂O₅

Purity: Min. 95%

Molecular weight: 400.51 g/mol

Ref: 3D-FM167440