CAS 471-95-4

Bufotalin

Description:

Bufotalin is a naturally occurring cardiac glycoside primarily derived from the skin of certain toads, particularly the Bufo species. It is known for its potent pharmacological effects, particularly in the context of its ability to influence cardiac function. Bufotalin exhibits a structure characterized by a steroid nucleus with a lactone ring, which is typical of cardiac glycosides. This compound has been studied for its potential therapeutic applications, including its use in traditional medicine for treating heart conditions, although it also poses risks due to its toxicity. Bufotalin functions by inhibiting the Na+/K+ ATPase enzyme, leading to increased intracellular calcium levels, which enhances cardiac contractility. However, its narrow therapeutic window necessitates caution, as overdoses can result in severe side effects, including arrhythmias and gastrointestinal disturbances. Research continues to explore its mechanisms of action and potential benefits in various medical applications, while also addressing safety concerns associated with its use.

Formula: C₂₆H₃₆O₆

InChI: InChI=1S/C26H36O6/c1-15(27)32-21-13-26(30)20-6-5-17-12-18(28)8-10-24(17,2)19(20)9-11-25(26,3)23(21)16-4-7-22(29)31-14-16/h4,7,14,17-21,23,28,30H,5-6,8-13H2,1-3H3/t17-,18+,19+,20-,21+,23+,24+,25-,26+/m1/s1

InChI key: InChIKey=VOZHMAYHYHEWBW-NVOOAVKYSA-N

SMILES: C[C@@]12[C@H]([C@@H](OC(C)=O)C[C@]1(O)[C@]3([C@](CC2)([C@]4(C)[C@](CC3)(C[C@@H](O)CC4)[H])[H])[H])C=5C=CC(=O)OC5

Synonyms:

• (3Beta,5Beta,8Xi,9Xi,16Beta)-16-(Acetyloxy)-3,14-Dihydroxybufa-20,22-Dienolide
• (3β,5β,16β)-16-(Acetyloxy)-3,14-dihydroxybufa-20,22-dienolide
• 16-(Acetyloxy)-3,14-Dihydroxybufa-20,22-Dienolide
• 3b,14,16b-Trihydroxy-5b-bufa-20,22-dienolide 16-acetate
• 5β-Bufa-20,22-dienolide, 3β,14,16β-trihydroxy-, 16-acetate
• Bufa-20,22-dienolide, 16-(acetyloxy)-3,14-dihydroxy-, (3β,5β,16β)-
• Bufotalin
• NSC 89596

Bufotalin

CAS: 471-95-4

Formula: C₂₆H₃₆O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 444.5604

Ref: IN-DA019FV4

Bufotalin

CAS: 471-95-4

Formula: C₂₆H₃₆O₆

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 444.57

Ref: 7W-GY1620

Bufotalin

CAS: 471-95-4

Bufotalin

Purity: ≥98%

Molecular weight: 444.56g/mol

Ref: 54-BUP08929

Bufotalin

CAS: 471-95-4

Formula: C₂₆H₃₆O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 444.57

Ref: 3B-B6325

Bufotalin

CAS: 471-95-4

Bufotalin is a cardiotoxic bufanolide steroid, cardiac glycoside analogue. Bufotalin has anti-cancer activity, it can induce apoptosis in Hep 3B cells, and caspase-8 inhibitor (Z-IETD) or wide-ranging caspase inhibitor (Z-VAD) significantly suppresses the bufotalin-induced apoptosis. Bufotalin is a powerful sensitizer of death receptor-induced apoptosis in cancer cells, it promotes death receptor-mediated cell death, especially TRAIL-induced apoptosis, through activation of caspase-3 and PARP-1.

Formula: C₂₆H₃₆O₆

Purity: 95%~99%

Molecular weight: 444.568

Ref: BP-BP0290

Bufotalin

CAS: 471-95-4

1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.

Formula: C₂₆H₃₆O₆

Purity: 99.45% - 99.91%

Color and Shape: White To Off-White Solid

Molecular weight: 444.56

Ref: TM-T5A2461

γ-Bufotalin

CAS: 471-95-4

gamma-Bufotalin is a bufadienolide compound, which is a type of steroid. It is sourced from toad venom, specifically from the parotoid glands of toads belonging to the Bufonidae family. This compound exhibits its mode of action primarily through inhibition of cellular ion pumps, particularly the Na⁺/K⁺-ATPase, leading to an increase in intracellular calcium levels. This mechanism induces apoptosis in certain cancer cell lines, providing a potential pathway for therapeutic intervention.

Formula: C₂₆H₃₆O₆

Purity: Min. 95%

Molecular weight: 444.56 g/mol

Ref: 3D-FB42755