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CAS 47141-42-4

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Levobunolol

Description:
Levobunolol is a non-selective beta-adrenergic antagonist primarily used in the treatment of glaucoma and ocular hypertension. It is characterized by its ability to reduce intraocular pressure by decreasing the production of aqueous humor in the eye. As a racemic mixture, levobunolol is the levorotatory isomer of bunolol, which enhances its therapeutic efficacy while minimizing side effects. The substance is typically administered as an eye drop solution and has a relatively long duration of action. Levobunolol is known for its favorable pharmacokinetic profile, including good ocular penetration and a low systemic absorption rate, which helps reduce systemic side effects commonly associated with beta-blockers. Its chemical structure includes a phenolic hydroxyl group, contributing to its solubility and stability in aqueous solutions. Additionally, levobunolol may exhibit some local anesthetic properties, further aiding in its application in ophthalmology. Overall, its effectiveness and safety profile make it a valuable option in managing elevated intraocular pressure.
Formula:C17H25NO3
InChI:InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1
InChI key:InChIKey=IXHBTMCLRNMKHZ-LBPRGKRZSA-N
SMILES:O(C[C@H](CNC(C)(C)C)O)C1=C2C(=CC=C1)C(=O)CCC2
Synonyms:
  • Levobunolol
  • 1(2H)-Naphthalenone, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-, (S)-
  • l-Bunolol
  • 1(2H)-Naphthalenone, 5-[(2S)-3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-
  • Levobunololum
  • 5-[(2S)-3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone
  • 1(2H)-Naphthalenone, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-, (S)-
  • Levobunolol [INN:BAN]
  • CCRIS 4375
  • UNII-G6317AOI7K
  • See more synonyms
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