CAS 472-11-7

Ruscogenin

Description:

Ruscogenin is a natural steroidal saponin derived from the plant genus Ruscus, commonly known as butcher's broom. It is characterized by its molecular structure, which includes a steroid backbone with a sugar moiety, contributing to its saponin classification. Ruscogenin exhibits various biological activities, including anti-inflammatory, antioxidant, and vasoprotective effects, making it of interest in pharmacological research. Its mechanism of action often involves modulation of cellular signaling pathways, which can influence vascular health and reduce edema. Additionally, Ruscogenin has been studied for its potential in treating conditions such as chronic venous insufficiency and hemorrhoids. The compound is typically extracted from plant sources and may be utilized in herbal medicine and dietary supplements. Due to its bioactive properties, Ruscogenin is also investigated for its potential therapeutic applications in various health conditions, although further research is needed to fully elucidate its efficacy and safety profile.

Formula: C₂₇H₄₂O₄

InChI: InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key: InChIKey=QMQIQBOGXYYATH-IDABPMKMSA-N

SMILES: C[C@@]12[C@@]3([C@@](O[C@@]4([C@H]3C)CC[C@@H](C)CO4)(C[C@]1([C@]5([C@](CC2)([C@]6(C)C(=CC5)C[C@@H](O)C[C@H]6O)[H])[H])[H])[H])[H]

Synonyms:

• (1beta,3beta,22xi,25R)-spirost-5-en-1,3-diol
• (1beta,3beta,25R)-spirost-5-en-1,3-diol
• (1β,3β,25R)-Spirost-5-ene-1,3-diol
• 25<span class="text-smallcaps">D</span>-Spirost-5-ene-1β,3β-diol
• 25R-Ruscogenin
• Ruscogenin
• Ruscogenine
• Spiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-[2H]pyran], spirost-5-ene-1,3-diol deriv.
• Spirost-5-ene-1,3-diol, (1β,3β,25R)-
• Spirost-5-ene-1β,3β-diol, (25R)-

Ruscogenin

CAS: 472-11-7

Ruscogenin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₂₇H₄₂O₄

Purity: (HPLC) ≥95%

Color and Shape: Powder

Molecular weight: 430.63

Ref: 11-3581

RUSCOGENINS CRS

CAS: 472-11-7

RUSCOGENINS CRS

Formula: C₂₇H₄₂O₄

Molecular weight: 430.62

Ref: 41-Y0000494

Ruscogenin

CAS: 472-11-7

Formula: C₂₇H₄₂O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 430.6200

Ref: IN-DA00D8QY

Ruscogenin

CAS: 472-11-7

Formula: C₂₇H₄₂O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 430.63

Ref: 7W-GY0470

Ruscogenin

CAS: 472-11-7

Ruscogenin

Purity: ≥98%

Molecular weight: 430.62g/mol

Ref: 54-BUP03396

Ruscogenin

CAS: 472-11-7

Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities.Ruscogenin significantly attenuates LPS-induced acute lung injury (ALI )via inhibiting expressions of TF and iNOS and NF-κB p65 activation, it inhibits activation of neutrophil through cPLA 2 , PAK, Akt, MAPKs, cAMP, and PKA signaling pathways.

Formula: C₂₇H₄₂O₄

Purity: 95%~99%

Molecular weight: 430.629

Ref: BP-BP1231

Ruscogenin-d3

CAS: 472-11-7

Formula: C₂₇H₃₉D₃O₄

Molecular weight: 433.65

Ref: 4Z-R-120002

Ruscogenin

CAS: 472-11-7

1.

Formula: C₂₇H₄₂O₄

Purity: 99.69% - 99.87%

Color and Shape: Solid

Molecular weight: 430.62

Ref: TM-T6S1256

Ruscogenin

CAS: 472-11-7

Formula: C₂₇H₄₂O₄

Molecular weight: 430.63

Ref: 4Z-R-120001

Ruscogenin

CAS: 472-11-7

Oxygen-heterocyclic compound

Formula: C₂₇H₄₂O₄

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 430.63

Ref: 5G-89268

Ruscogenin

CAS: 472-11-7

Applications A major steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities. Studies suggest that it inhibits adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-α (TNF-α) in a concentration-dependent manner.
References Huang, Y. et al.: Drug Dev. Res., 69, 196 (2008); Huang, Y. et al.: J. Pharmacol. Sci., 108, 198 (2008); Song, J. et al.: J. Pharmacol. Sci., 113, 409 (2010);

Formula: C₂₇H₄₂O₄

Color and Shape: Neat

Molecular weight: 430.62

Ref: TR-R701750

Ruscogenin

CAS: 472-11-7

Ruscogenin is a steroidal saponin, which is derived from the underground parts of plants belonging to the genus *Ruscus*, commonly known as butcher's broom. This compound is extracted primarily from the rhizomes of these plants. Its mode of action involves modulating inflammatory pathways by inhibiting the release of pro-inflammatory cytokines, thereby reducing inflammation. Additionally, ruscogenin has been observed to enhance vascular integrity and reduce capillary permeability.

Formula: C₂₇H₄₂O₄

Purity: Min. 95%

Molecular weight: 430.62 g/mol

Ref: 3D-FR27770