CAS 472-26-4

Telocinobufagin

Description:

Telocinobufagin is a potent steroidal compound classified as a bufadienolide, primarily derived from the skin secretions of certain toads, particularly those in the Bufo genus. It exhibits a complex structure characterized by a steroid backbone with specific functional groups that contribute to its biological activity. Telocinobufagin is known for its cardiotonic properties, which means it can influence heart muscle contractions, making it of interest in pharmacological research. Additionally, it has been studied for its potential anti-cancer properties, as it may induce apoptosis in certain cancer cell lines. The compound interacts with various cellular targets, including ion channels and enzymes, which can lead to significant physiological effects. However, due to its potent biological activity, telocinobufagin can also be toxic at higher concentrations, necessitating careful handling and dosage considerations in research and potential therapeutic applications. Its unique characteristics make it a subject of interest in both toxicology and medicinal chemistry.

Formula: C₂₄H₃₄O₅

InChI: InChI=1S/C24H34O5/c1-21-9-5-16(25)13-23(21,27)11-7-19-18(21)6-10-22(2)17(8-12-24(19,22)28)15-3-4-20(26)29-14-15/h3-4,14,16-19,25,27-28H,5-13H2,1-2H3/t16-,17+,18-,19+,21+,22+,23-,24-/m0/s1

InChI key: InChIKey=PBSOJKPTQWWJJD-ZBDZJSKLSA-N

SMILES: O[C@@]12[C@]3([C@@]([C@]4(C)[C@](O)(CC3)C[C@@H](O)CC4)(CC[C@]1(C)[C@H](CC2)C=5C=CC(=O)OC5)[H])[H]

Synonyms:

• (3Beta,5Beta)-3,5,14-Trihydroxybufa-20,22-Dienolide
• (3β,5β)-3,5,14-Trihydroxybufa-20,22-dienolide
• 3Β,5,14-Trihydroxy-5Β-Bufa-20,22-Dienolide
• 5.beta.-Bufa-20,22-dienolide, 3.beta.,5,14-trihydroxy-
• 5β-Bufa-20,22-dienolide, 3β,5,14-trihydroxy-
• Bufa-20,22-Dienolide, 3,5,14-Trihydroxy-, (3Beta,5Beta)-
• Bufa-20,22-Dienolide, 3,5,14-Trihydroxy-, (3Beta,5Beta,8Xi,9Xi)-
• Bufa-20,22-dienolide, 3,5,14-trihydroxy-, (3.beta.,5.beta.)-
• Bufa-20,22-dienolide, 3,5,14-trihydroxy-, (3β,5β)-
• NSC 119989
• NSC 90782
• Telecinobufagin
• Telobufotoxin
• Telocinobufagin
• Telocinobufogenin
• 5-[(3S,5S,8R,9S,10R,13R,14S,17R)-3,5,14-trihydroxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one
• Telocinobufagin (Telobufotoxin
• 3β,5,14-Trihydroxy-5β-bufa-20,22-dienolide USP/EP/BP
• 3β,5,14-Trihydroxy-5β,14β-bufa-20,22-dienolide

3β,5,14-Trihydroxy-5β-bufa-20,22-dienolide

CAS: 472-26-4

Formula: C₂₄H₃₄O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 402.5238

Ref: IN-DA00DB9A

Telocinobufagin

CAS: 472-26-4

Telocinobufagin

Purity: ≥98%

Molecular weight: 402.52g/mol

Ref: 54-BUP21062

Telocinobufagin

CAS: 472-26-4

Formula: C₂₄H₃₄O₅

Molecular weight: 402.53

Ref: 7W-GY7301

Telocinobufagin

CAS: 472-26-4

Telocinobufagin (TCB), a bufadienolide extracted from Bufo paracnemis parotoid glands, shows a reversible local anesthetic action, similar to BUPI, however, without cardiac toxicity in vitro.

Formula: C₂₄H₃₄O₅

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 402.531

Ref: BP-BP1370

Telocinobufagin

CAS: 472-26-4

Telocinobufagin, a potent digitalis-like factor, reduces spleen bacteria and boosts survival in immunized mice, showing promise as an immunotherapy for cancer.

Formula: C₂₄H₃₄O₅

Purity: 98.42% - 99.74%

Color and Shape: Solid

Molecular weight: 402.52

Ref: TM-T4A2462

Telocinobufogenin

Controlled Product

CAS: 472-26-4

Applications Telocinobufagin is isolated as a major component from skin secretion of the toad Bufo rubescens. Telocinobufogenin is a novel antibiotic cardiotonic.
References Akizawa, T., et al.: Chem. Pharm. Bull., 42, 754 (1994); Hancock, R., et al.: Antimicrob. Agents Chemother., 43, 1317 (1999); Jing, Y., et al.: J. Cancer Res., 85, 645 (1994); Kamano, Y., et al.: J. Med. Chem., 45, 5440 (2002); Schoner, W., et al.: Eur. J. Biochem., 269, 2440 (2002); Cunha Filho, G., et al.: Toxicon, 45, 777 (2005)

Formula: C₂₄H₃₄O₅

Color and Shape: Neat

Molecular weight: 402.52

Ref: TR-T017060