CAS 4732-82-5

3′-Iodothyronine

Description:

3′-Iodothyronine, also known as liothyronine or T3, is a thyroid hormone that plays a crucial role in regulating metabolism, growth, and development in the body. It is an iodinated derivative of thyronine, characterized by the presence of an iodine atom at the 3′ position of the phenolic ring. This compound is typically found in the form of a white to off-white crystalline powder and is soluble in water, making it bioavailable for physiological functions. 3′-Iodothyronine is involved in various biochemical processes, including the modulation of gene expression and the enhancement of cellular respiration. It is often used in clinical settings to treat hypothyroidism and other thyroid-related disorders. The hormone exerts its effects by binding to thyroid hormone receptors, influencing metabolic pathways and energy expenditure. Due to its significant role in metabolism, any imbalance in its levels can lead to various health issues, underscoring the importance of maintaining proper thyroid function.

Formula: C₁₅H₁₄INO₄

InChI: InChI=1S/C15H14INO4/c16-12-8-11(5-6-14(12)18)21-10-3-1-9(2-4-10)7-13(17)15(19)20/h1-6,8,13,18H,7,17H2,(H,19,20)/t13-/m0/s1

InChI key: InChIKey=RUIUIJSMLKJUDC-ZDUSSCGKSA-N

SMILES: O(C1=CC(I)=C(O)C=C1)C2=CC=C(C[C@@H](C(O)=O)N)C=C2

Synonyms:

• 3'-Monoiodothyronine
• 3'-T1
• 3′-Iodo-<span class="text-smallcaps">L</span>-thyronine
• 3′-Iodo-l-thyronine
• 3′-Iodothyronine
• 4732-82-5
• <span class="text-smallcaps">L</span>-Tyrosine, O-(4-hydroxy-3-iodophenyl)-
• Alanine, 3-[p-(4-hydroxy-3-iodophenoxy)phenyl]-
• O-(4-Hydroxy-3-iodophenyl)-<span class="text-smallcaps">L</span>-tyrosine
• L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-
• O-(4-Hydroxy-3-iodophenyl)-L-tyrosine

3’-Iodo-L-thyronine

CAS: 4732-82-5

Applications 3’-Iodo-L-thyronine is a metabolite of thyroid hormone which is known to be important for optimal development of the human central nervous system.
References Chan, S., et al.: Develop. Brain Res., 138, 109 (2002);

Formula: C₁₅H₁₄INO₄

Color and Shape: Light Beige

Molecular weight: 399.18

Ref: TR-I721505

3’-Iodo-L-thyronine-13C6

Controlled Product

CAS: 4732-82-5

Formula: C₆C₉H₁₄INO₄

Color and Shape: Neat

Molecular weight: 405.136

Ref: TR-I721507

3’-Iodo-L-thyronine

CAS: 4732-82-5

3'-Iodo-L-thyronine is a cytosolic thyroid hormone that is produced from T4 in the liver, with a ph optimum of 7.3. It is an active substance that can be found in human serum and tissues, such as the heart and liver. 3'-Iodo-L-thyronine is expressed at high levels in cardiac hypertrophy and myocardial infarction patients, as well as in cirrhosis patients. In addition, this drug has been shown to have enzyme activities that are necessary for lipid metabolism, protein synthesis, and carbohydrate metabolism. 3'-Iodo-L-thyronine also has hypothyroid effects on the body due to its ability to reduce serum levels of T3 and T4 hormones.

Formula: C₁₅H₁₄INO₄

Purity: Min. 95%

Molecular weight: 399.18 g/mol

Ref: 3D-EAA73282