CAS 474922-22-0

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)] ammonium salt

Description:

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)] ammonium salt, commonly referred to as DSPE-PEG-Mal, is a phospholipid derivative that features a hydrophobic tail composed of two stearic acid chains and a hydrophilic head group that includes a phosphoethanolamine moiety linked to a maleimide-functionalized polyethylene glycol (PEG). This compound is characterized by its amphiphilic nature, which allows it to self-assemble into lipid bilayers or micelles in aqueous environments, making it particularly useful in drug delivery systems and nanocarrier formulations. The maleimide group provides a reactive site for conjugation with thiol-containing molecules, facilitating targeted delivery and bioconjugation applications. DSPE-PEG-Mal is often utilized in the development of liposomes and nanoparticles for biomedical applications, including targeted therapy and imaging. Its stability, biocompatibility, and ability to enhance solubility of hydrophobic drugs are key attributes that contribute to its widespread use in pharmaceutical and biotechnological research.

Formula: (C₂H₄O)nC₅₁H₉₂N₃O₁₃P·H₃N

Synonyms:

• Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]-, ammonium salt
• 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)] ammonium salt
• DSPE-PEG maleimide
• Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]-, ammonium salt (1:1)
• DSPE-PEG 2000 maleimide

DSPE-PEG(2000) Maleimide (ammonium salt)

CAS: 474922-22-0

Formula: C₅₃H₉₉N₄O₁₄P

Purity: 97%

Color and Shape: Solid

Molecular weight: 1047.3453

Ref: IN-DA00DHR0

DSPE-PEG5000-Mal ammonium

CAS: 474922-22-0

DSPE-PEG5000-Mal ammonium is a lipid-PEG conjugate for nanostructured drug carriers, enhancing circulation,stability,and biocompatibility of therapeutic agents.

Formula: (C₂H₄O)nC₅₁H₉₂N₁O₁₃P·H₃N

Color and Shape: Solid

Molecular weight: 2000(Average)

Ref: TM-T84748

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (ammonium salt)

CAS: 474922-22-0

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (ammonium salt) is a lipid conjugate consisting of 1,2-distearoyl-sn-glycero-PE and maleimide(polyethylene glycol)-2000. It is synthesized by reacting the PEGylated derivative with an amine terminated lipid. The resulting product is a water soluble compound that can be used to prepare immunoliposomes or siRNA delivery systems.

Formula: C₁₃₉H₂₇₁N₄O₅₇P

Purity: Min. 95%

Molecular weight: 2,941.61 g/mol

Ref: 3D-ZTA92222