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CAS 474922-77-5

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1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)] ammonium salt

Description:
1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)] ammonium salt, commonly referred to as DSPE-PEG, is a phospholipid derivative that features a hydrophobic tail composed of two stearic acid chains and a hydrophilic head group containing polyethylene glycol (PEG). This amphiphilic nature allows it to form stable lipid bilayers and micelles, making it particularly useful in drug delivery systems and nanomedicine. The PEG component enhances solubility in aqueous environments and provides a stealth effect, reducing protein adsorption and prolonging circulation time in biological systems. DSPE-PEG is often utilized in the formulation of liposomes and nanoparticles for targeted drug delivery, as it can facilitate the incorporation of therapeutic agents while improving biocompatibility. Additionally, its ammonium salt form enhances its solubility and stability in various formulations. Overall, DSPE-PEG is a versatile compound widely employed in pharmaceutical and biomedical applications due to its unique structural characteristics and functional properties.
Formula:(C2H4O)nC43H84NO10P·H3N
InChI:InChI=1S/C45H88NO11P/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-43(47)54-40-42(41-56-58(50,51)55-37-36-46-45(49)53-39-38-52-3)57-44(48)35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h42H,4-41H2,1-3H3,(H,46,49)(H,50,51)
InChI key:InChIKey=ULSDQCPIMGVPAF-UHFFFAOYSA-N
SMILES:C(COP(OCCNC(OCCOC)=O)(=O)O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.N
Synonyms:
  • MPEG2000-DSPE
  • Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-, ammonium salt (1:1)
  • DSPE-mPEG
  • DSPE-mPEG 2000
  • DSPE-PEG-methoxy 2000
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