CAS 475110-96-4

2-(Difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-1H-benzimidazole

Description:

2-(Difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-1H-benzimidazole is a chemical compound characterized by its complex structure, which includes a benzimidazole core and a triazine moiety. The presence of difluoromethyl groups suggests that it may exhibit unique electronic properties and reactivity due to the electronegative fluorine atoms. The morpholine groups contribute to its potential solubility and interaction with biological systems, making it of interest in pharmaceutical applications. This compound may possess specific biological activities, potentially acting as a herbicide or fungicide, given its structural features that are often associated with agrochemical properties. Its molecular weight, solubility, and stability under various conditions would be critical for its practical applications. Additionally, the compound's synthesis and purification methods would be essential for obtaining it in a usable form for research or industrial purposes. Safety data, including toxicity and environmental impact, would also be important considerations for handling and application.

Formula: C₁₉H₂₁F₂N₇O₂

InChI: InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2

InChI key: InChIKey=HGVNLRPZOWWDKD-UHFFFAOYSA-N

SMILES: C(F)(F)C=1N(C=2C(N1)=CC=CC2)C=3N=C(N=C(N3)N4CCOCC4)N5CCOCC5

Synonyms:

• 1H-Benzimidazole, 2-(difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-
• 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-bis(morpholino)-1,3,5-triazine
• 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine
• 2-(Difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-1H-benzimidazole
• Tcmdc-137004
• Zstk 474
• Zstk474
• 4,4′-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine

ZSTK474

CAS: 475110-96-4

Formula: C₁₉H₂₁F₂N₇O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 417.4125

Ref: IN-DA00DB7V

4,4'-(6-(2-(Difluoromethyl)-1H-Benzo[D]Imidazol-1-Yl)-1,3,5-Triazine-2,4-Diyl)Dimorpholine

CAS: 475110-96-4

4,4'-(6-(2-(Difluoromethyl)-1H-Benzo[D]Imidazol-1-Yl)-1,3,5-Triazine-2,4-Diyl)Dimorpholine

Purity: 98%

Molecular weight: 417.41g/mol

Ref: 54-PC108908

ZSTK474

CAS: 475110-96-4

ZSTK474

Purity: ≥98%

Molecular weight: 417.41g/mol

Ref: 54-BUP15432

ZSTK474

CAS: 475110-96-4

Ref: 7W-GW6410

ZSTK474

CAS: 475110-96-4

PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential

Formula: C₁₉H₂₁F₂N₇O₂

Purity: 98.29% - 99.95%

Color and Shape: White Powder

Molecular weight: 417.41

Ref: TM-T6168

ZSTK474

CAS: 475110-96-4

Purity: 99.0%

Color and Shape: Solid

Molecular weight: 417.421

Ref: 10-F050801

ZSTK 474

Controlled Product

CAS: 475110-96-4

Applications ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase (PI3K) isoforms. Potent PI3K inhibitor.
References Yaguchi, S., et al.: J. Natl. Cancer Inst., 98, 545 (2006); Kong, D., et al.: Cancer Sci., 98, 1638 (2007); Kong, D., et al.: Eur. J. Cancer, 45, 857 (2009); Marone, R., et al.: Mol. Cancer Res., 7, 601 (2009); Yang, S., et al.: PLoS One, 6, e26343 (2011); Haruta, K., et al.: Inflamm, Res., 61, 551 (2012);

Formula: C₁₉H₂₁F₂N₇O₂

Color and Shape: Neat

Molecular weight: 417.41

Ref: TR-Z701000

ZSTK474

CAS: 475110-96-4

ZSTK474 is a novel compound that has been shown to have autophagy-inducing properties. Studies have found that ZSTK474 inhibits the growth of human cancer cells in vitro and in vivo, and also has inhibitory effects on epithelial mesenchymal transition (EMT) and metastasis. ZSTK474 targets the mitochondrial membrane potential and ATP production, which reduces cellular energy metabolism. These inhibitory effects lead to increased autophagy in cells, which may be due to the inhibition of protein synthesis and cell cycle progression. ZSTK474 has also been shown to induce apoptosis in cancer cells by inducing DNA damage.

Formula: C₁₉H₂₁O₂N₇F₂

Purity: Min. 95%

Molecular weight: 417.17248

Ref: 3D-FD34127