CAS 475207-59-1: Nexavar

Description:Nexavar, with the CAS number 475207-59-1, is the trade name for sorafenib, a small molecule tyrosine kinase inhibitor used primarily in cancer treatment. It is characterized by its ability to inhibit multiple kinases involved in tumor cell proliferation and angiogenesis, including Raf kinases and receptor tyrosine kinases such as VEGFR and PDGFR. Sorafenib is typically administered orally and is known for its role in treating advanced renal cell carcinoma and hepatocellular carcinoma. The compound is a pale yellow to off-white solid, with a molecular formula that includes carbon, hydrogen, nitrogen, oxygen, and fluorine. Its mechanism of action involves disrupting the signaling pathways that promote cancer cell growth and blood vessel formation, thereby slowing tumor progression. Nexavar is often associated with side effects such as fatigue, diarrhea, and skin reactions, which are important considerations in patient management. Overall, sorafenib represents a significant advancement in targeted cancer therapies, offering a strategic approach to combat specific malignancies.

Formula:C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S

InChI:InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)

InChI key:InChIKey=IVDHYUQIDRJSTI-UHFFFAOYSA-N

SMILES:O=C(NC1=CC=C(OC=2C=CN=C(C2)C(=O)NC)C=C1)NC3=CC=C(Cl)C(=C3)C(F)(F)F.O=S(=O)(O)C1=CC=C(C=C1)C

Synonyms:
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, 4-methylbenzenesulfonate (1:1)
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, mono(4-methylbenzenesulfonate)
4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate
BAY 43-9006 mono-p-tosylate
Bay 54-9085
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea Tolsylate
Nexavar
Sorafenib TsOH salt
Sorafenib p-toluenesulfonate
Sorafenib-D3
See more synonyms
Sorafenib tosylate

Found 17 products.

Product data	Purity	Price range	Estimated delivery
Sorafenib Tosylate REF: 3B-N1229CAS: 475207-59-1	>98.0%(T)(HPLC)	85.00 €	Fri 04 Apr 25
Sorafenib CRS REF: 41-Y0002098CAS: 475207-59-1	- - -	115.00 €	Wed 09 Apr 25
Sorafenib tosilate CRS REF: 41-Y0002224CAS: 475207-59-1	- - -	152.00 €	Wed 09 Apr 25
Sorafenib for peak identification A CRS REF: 41-Y0002488CAS: 475207-59-1	- - -	115.00 €	Wed 09 Apr 25
Sorafenib for peak identification CRS REF: 41-Y0002236CAS: 475207-59-1	- - -	152.00 €	Wed 09 Apr 25
Sorafenib Tosylate REF: 45-1615876CAS: 475207-59-1	- - -	2,578.00 €	Thu 10 Apr 25
Sorafenib tosylate REF: TM-T0093CAS: 475207-59-1	99.2% - 99.94%	44.00 €~95.00 €	Fri 11 Apr 25
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N2-methylpyridine-2-carboxamide mono (4-methylbenzenesulfonate) REF: IN-DA0035M4CAS: 475207-59-1	98%	24.00 €~305.00 €	Fri 11 Apr 25
Sorafenib Tosylate REF: 4Z-S-2738CAS: 475207-59-1	- - -	To inquire	Mon 14 Apr 25
Sorafenib tosylate REF: 7W-GK5261CAS: 475207-59-1	≥ 98.0% (dried basis)	To inquire	Mon 14 Apr 25
Sorafenib tosylate REF: AC-46571CAS: 475207-59-1	- - -	To inquire	Mon 14 Apr 25
Sorafenib Tosylate REF: 86-MM3585.00CAS: 475207-59-1	- - -	1,499.00 €	Mon 14 Apr 25
Sorafenib tosylate REF: 54-BISN0216CAS: 475207-59-1	99%	37.00 €~892.00 €	Mon 21 Apr 25
Sorafenib Tosylate REF: TR-S676845CAS: 475207-59-1	- - -	94.00 €~194.00 €	Mon 21 Apr 25
Sorafenib tosylate REF: 3D-FS10808CAS: 475207-59-1	Min. 95%	143.00 €~1,990.00 €	Tue 22 Apr 25
Sorafenib tosylate - Bio-X ™ REF: 3D-BS164414CAS: 475207-59-1	Min. 95%	147.00 €	Tue 22 Apr 25
Sorafenib, p-Toluenesulfonate Salt REF: 10-F050782CAS: 475207-59-1	99.0%	- - -	Discontinued product