CAS 475479-34-6

Aleglitazar

Description:

Aleglitazar is a synthetic compound that belongs to the class of dual peroxisome proliferator-activated receptor (PPAR) agonists, specifically targeting both PPAR-alpha and PPAR-gamma. This dual action is significant as it aims to improve lipid metabolism and enhance insulin sensitivity, making it a candidate for the treatment of metabolic disorders such as type 2 diabetes and dyslipidemia. The chemical structure of Aleglitazar features a thiazolidinedione moiety, which is characteristic of PPAR-gamma agonists, and it is designed to exhibit favorable pharmacokinetic properties. In preclinical and clinical studies, Aleglitazar has shown potential in reducing triglyceride levels and improving glycemic control. However, like many investigational drugs, its development has faced challenges, including safety and efficacy evaluations. As of the latest updates, Aleglitazar has not received regulatory approval for clinical use, and ongoing research continues to explore its therapeutic potential and safety profile.

Formula: C₂₄H₂₃NO₅S

InChI: InChI=1S/C24H23NO5S/c1-15-19(25-23(30-15)16-6-4-3-5-7-16)10-12-29-20-9-8-17(14-21(28-2)24(26)27)22-18(20)11-13-31-22/h3-9,11,13,21H,10,12,14H2,1-2H3,(H,26,27)/t21-/m0/s1

InChI key: InChIKey=DAYKLWSKQJBGCS-NRFANRHFSA-N

SMILES: C([C@@H](C(O)=O)OC)C1=C2C(=C(OCCC=3N=C(OC3C)C4=CC=CC=C4)C=C1)C=CS2

Synonyms:

• (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid
• (S)-2-Methoxy-3-[4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]benzo[b]thiophen-7-yl]propionic acid
• (αS)-α-Methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thiophene-7-propanoic acid
• Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αS)-
• R 1439
• Ro 0728804
• Aleglitazar

Aleglitazar

CAS: 475479-34-6

Aleglitazar

Purity: ≥98%

Molecular weight: 437.51g/mol

Ref: 54-BUP04754

Aleglitazar

CAS: 475479-34-6

Formula: C₂₄H₂₃NO₅S

Molecular weight: 437.51

Ref: 4Z-A-237001

Aleglitazar

CAS: 475479-34-6

Formula: C₂₄H₂₃NO₅S

Molecular weight: 437.51

Ref: ST-EA-CP-A303000

Aleglitazar

CAS: 475479-34-6

Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.

Formula: C₂₄H₂₃NO₅S

Purity: 99.03%

Color and Shape: Solid

Molecular weight: 437.51

Ref: TM-T14176