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CAS 4759-48-2

:

isotretinoin

Description:
Isotretinoin, with the CAS number 4759-48-2, is a synthetic retinoid, primarily used in the treatment of severe acne, particularly nodular acne that has not responded to other therapies. It is a derivative of vitamin A and functions by reducing sebum production, promoting cell turnover, and exhibiting anti-inflammatory properties. Isotretinoin is characterized by its lipophilic nature, which allows it to be absorbed well in the gastrointestinal tract when taken orally. The compound has a complex molecular structure, featuring a cyclohexene ring and multiple double bonds, contributing to its biological activity. It is known for its potential side effects, including teratogenicity, which necessitates strict guidelines for its use in women of childbearing age. Additionally, isotretinoin can cause dryness of the skin and mucous membranes, as well as alterations in liver function and lipid levels. Due to its potency and side effect profile, isotretinoin is typically prescribed under careful medical supervision, often as part of a comprehensive acne treatment plan.
Formula:C20H28O2
InChI:InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
InChI key:InChIKey=SHGAZHPCJJPHSC-XFYACQKRSA-N
SMILES:C(=C/C(=C/C=C/C(=C\C(O)=O)/C)/C)\C=1C(C)(C)CCCC1C
Synonyms:
  • (13Cis)-15-Oxidoretinal
  • (13Z)-Retinoic acid
  • 13-Cis-Retinoic Acid
  • 13-Cis-Vitamin A Acid
  • 13-Ra
  • 13-cis-β-Retinoic acid
  • 3,7-Dimethyl-9-(2,6,6-Trimethyl-1-Cyclohexen-1-Yl)-2-Cis-4-Trans-6-Trans-8-Trans-Nonatetraenoic Acid
  • Absorica
  • Accure
  • Accutane
  • See more synonyms
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products per page.Found 23 products.
  • 13-cis-Retinoic Acid-d5
    TRC
    + Info

    13-cis-Retinoic Acid-d5

    Controlled Product
    CAS:

    Applications 13-cis-Retinoic Acid-d5, is the labeled analogue of 13-cis-Retinoic Acid (R250000) used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
    References Lerche, C., et al.: Exp. Dermatol., 17, 972 (2008), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Gan, J., et al.: Chem. Res. Toxicol., 22, 690 (2009), Macejova, D., et al.: Toxicol. Lett., 184, 114 (2009), Chen, P., et al.: Toxicol. App. Pharmacol., 234, 143 (2009),

    Formula:C20H23D5O2
    Color and Shape:Neat
    Molecular weight:305.466

    Ref: TR-R250004

    1mg
    382.00€
    10mg
    2,479.00€
    25mg
    6,803.00€
  • 13-cis-Retinoic Acid-13C3
    TRC
    + Info

    13-cis-Retinoic Acid-13C3

    Controlled Product
    CAS:

    Applications 13-cis-Retinoic Acid-13C3, is the labeled analogue of 13-cis-Retinoic Acid (R250002), used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
    References Lerche, C., et al.: Exp. Dermatol., 17, 972 (2008), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Gan, J., et al.: Chem. Res. Toxicol., 22, 690 (2009), Macejova, D., et al.: Toxicol. Lett., 184, 114 (2009), Chen, P., et al.: Toxicol. App. Pharmacol., 234, 143 (2009),

    Formula:C3C17H28O2
    Color and Shape:Neat
    Molecular weight:303.413

    Ref: TR-R250003

    1mg
    529.00€
    10mg
    3,725.00€
  • Isotretinoin
    Biosynth
    + Info

    Isotretinoin

    Controlled Product
    CAS:

    An endogenous retinoic acid receptor (RAR) agonist that upregulates forkhead box class O (FoxO) transcription factor. Suppresses activity and proliferation of sebaceous glands. Used for treating nodulocystic acne. Induces differentiation, neurite outgrowth and inhibits proliferation of neuroblastoma cells. A potential chemopreventive agent in non-small cell lung cancer, head and neck squamous cell carcinoma and neuroblastoma.

    Formula:C20H28O2
    Purity:Min. 95%
    Molecular weight:300.44 g/mol

    Ref: 3D-BR164589

    100mg
    310.00€