CAS 475992-30-4

(11alpha)-16,16-difluoro-11,15-dihydroxy-9-oxoprostan-1-oic acid

Description:

(11alpha)-16,16-difluoro-11,15-dihydroxy-9-oxoprostan-1-oic acid is a synthetic compound that belongs to the class of prostaglandin analogs. This substance is characterized by the presence of two fluorine atoms at the 16 position, which can significantly influence its biological activity and stability. The compound features hydroxyl groups at the 11 and 15 positions, contributing to its potential reactivity and interaction with biological systems. The oxo group at the 9 position indicates the presence of a carbonyl functional group, which can play a role in its chemical behavior. This compound is of interest in pharmaceutical research, particularly for its potential anti-inflammatory and analgesic properties, similar to other prostaglandin derivatives. Its unique structural modifications may enhance its efficacy or alter its pharmacokinetic profile compared to natural prostaglandins. As with many synthetic compounds, understanding its solubility, stability, and interaction with biological targets is crucial for its application in medicinal chemistry.

Formula: C₂₀H₃₄F₂O₅

InChI: InChI=1/C20H34F2O5/c1-2-3-12-20(21,22)18(25)11-10-15-14(16(23)13-17(15)24)8-6-4-5-7-9-19(26)27/h14-15,17-18,24-25H,2-13H2,1H3,(H,26,27)/t14-,15-,17-,18?/m1/s1

SMILES: CCCCC(C(CC[C@@H]1[C@@H](CCCCCCC(=O)O)C(=O)C[C@H]1O)O)(F)F

15-Hydroxy Lubiprostone-d7

CAS: 475992-30-4

Formula: C₂₀H₂₇D₇F₂O₅

Color and Shape: Colorless Oil

Molecular weight: 399.53

Ref: 4Z-L-2117

15-Hydroxy Lubiprostone

CAS: 475992-30-4

Formula: C₂₀H₃₄F₂O₅

Color and Shape: Colorless Liquid

Molecular weight: 392.48

Ref: 4Z-L-213

15-Hydroxy Lubiprostone-d4

CAS: 475992-30-4

Formula: C₂₀H₃₀D₄F₂O₅

Color and Shape: Colorless Liquid

Molecular weight: 396.51

Ref: 4Z-L-214

15-Hydroxy Lubiprostone Dicyclohexylammonium Salt-d7

Controlled Product

CAS: 1217511-55-1, 475992-30-4

Formula: C₃₂H₅₀D₇F₂NO₅

Color and Shape: Colourless To Off-White

Molecular weight: 580.84

Ref: TR-H943892

15-Hydroxy Lubiprostone

CAS: 475992-30-4

Formula: C₂₀H₃₄F₂O₅

Molecular weight: 392.48

Ref: ST-EA-CP-L128002

13,14-dihydro-16,16-difluoro Prostaglandin E1

CAS: 475992-30-4

Prostaglandin E1 (PGE1), synthesized through cyclooxygenase-mediated metabolism of dihomo-γ-linolenic acid (DGLA), functions by inhibiting platelet aggregation (IC50= 40 nM) and enhancing vasodilation. Its analog, 13,14-dihydro-16,16-difluoro PGE1, and the metabolite, 13,14-dihydro PGE1, both retain similar anti-aggregatory properties to the original compound. The inclusion of two electron-withdrawing fluorine atoms in 13,14-dihydro-16,16-difluoro PGE1 is believed to increase molecular stability and potentially extend bioavailability by resisting hydrolytic degradation.

Formula: C₂₀H₃₄F₂O₅

Color and Shape: Solid

Molecular weight: 392.484

Ref: TM-T84513