CAS 47608-32-2: Trospium

Description:Trospium is a synthetic antimuscarinic agent primarily used in the treatment of overactive bladder and urinary incontinence. It functions by blocking the action of acetylcholine on muscarinic receptors in the bladder, thereby reducing involuntary contractions and increasing bladder capacity. Trospium is characterized by its quaternary ammonium structure, which contributes to its limited ability to cross the blood-brain barrier, minimizing central nervous system side effects. The substance is typically administered in its chloride salt form, enhancing its solubility and bioavailability. Trospium is generally well-tolerated, though it may cause side effects such as dry mouth, constipation, and urinary retention. Its pharmacokinetics indicate a relatively short half-life, necessitating multiple daily doses for effective management of symptoms. Additionally, it is important to consider potential drug interactions, particularly with other anticholinergic medications, which may exacerbate side effects. Overall, Trospium represents a valuable therapeutic option for patients suffering from urinary disorders.

Formula:C₂₅H₃₀NO₃

InChI:InChI=1/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1/t21-,22+,23+

InChI key:InChIKey=OYYDSUSKLWTMMQ-JKHIJQBDNA-N

SMILES:O=C(OC1CC2CCC(C1)[N+]32CCCC3)C(O)(C=4C=CC=CC4)C=5C=CC=CC5

Synonyms:
(1α,3α,5α)-3-[(2-Hydroxy-2,2-diphenylacetyl)oxy]spiro[8-azoniabicyclo[3.2.1]octane-8,1′-pyrrolidinium]
Trospium cation
Spiro[8-azoniabicyclo[3.2.1]octane-8,1′-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, (1α,3α,5α)-
Trospium
Spiro[8-azoniabicyclo[3.2.1]octane-8,1′-pyrrolidinium], 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-, (1α,3α,5α)-