CAS 476371-89-8

(2R,​3E)​-2,​4-​Dimethyl-​2-​[(1-​oxopropyl)​thio]​-​3,​5-​hexadienoic Acid Ethyl Ester

Controlled Product

CAS: 476371-89-8

Applications (2R,​3E)​-2,​4-​Dimethyl-​2-​[(1-​oxopropyl)​thio]​-​3,​5-​hexadienoic Acid Ethyl Ester is an intermediate in synthesizing (R)-(+)-Thiolactomycin (T350880). It is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).
References Kapilashrami, K., et al.: J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al.: J. Pharm. Res., 4, 4618 (2011); Katane, M., et al.: Biochimie, 92, 1371 (2010)

Formula: C₁₃H₂₀O₃S

Color and Shape: Neat

Molecular weight: 256.36

Ref: TR-D471970