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CAS 476436-68-7

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Naveglitazar

Description:
Naveglitazar is a synthetic compound that belongs to the class of dual peroxisome proliferator-activated receptor (PPAR) agonists, specifically targeting PPAR-alpha and PPAR-gamma. It has been investigated primarily for its potential therapeutic applications in metabolic disorders, particularly type 2 diabetes and obesity. The compound exhibits properties that may enhance insulin sensitivity and promote lipid metabolism, making it a candidate for managing dyslipidemia and improving glycemic control. Naveglitazar's mechanism of action involves modulating gene expression related to glucose and lipid homeostasis, which can lead to beneficial metabolic effects. In preclinical studies, it has shown promise in reducing body weight and improving metabolic profiles. However, as with many investigational drugs, the safety and efficacy profiles are subject to ongoing research and clinical trials. Its chemical structure and specific interactions at the molecular level contribute to its pharmacological effects, but detailed information on its pharmacokinetics and long-term effects remains to be fully elucidated.
Formula:C25H26O6
InChI:InChI=1S/C25H26O6/c1-28-24(25(26)27)18-19-8-10-20(11-9-19)29-16-5-17-30-21-12-14-23(15-13-21)31-22-6-3-2-4-7-22/h2-4,6-15,24H,5,16-18H2,1H3,(H,26,27)/t24-/m0/s1
InChI key:InChIKey=OKJHGOPITGTTIM-DEOSSOPVSA-N
SMILES:O(C1=CC=C(OCCCOC2=CC=C(C[C@@H](C(O)=O)OC)C=C2)C=C1)C3=CC=CC=C3
Synonyms:
  • Naveglitazar
  • Benzenepropanoic acid, α-methoxy-4-[3-(4-phenoxyphenoxy)propoxy]-, (αS)-
  • LY 519818
  • (αS)-α-Methoxy-4-[3-(4-phenoxyphenoxy)propoxy]benzenepropanoic acid
  • (2S)-2-Methoxy-3-[4-[3-(4-phenoxyphenoxy)propoxy]phenyl]propanoic acid
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