CAS 477-49-6

Podophyllotoxone

Description:

Podophyllotoxone, with the CAS number 477-49-6, is a naturally occurring chemical compound derived from the roots of the Podophyllum plant, commonly known as the mayapple. It is classified as a lignan and is structurally related to podophyllin, a mixture of compounds used historically in medicine. Podophyllotoxone exhibits significant biological activity, particularly as an antitumor agent, and has been studied for its potential in cancer therapy due to its ability to inhibit cell division. The compound is known to interact with microtubules, disrupting mitotic spindle formation, which is crucial for cell division. In addition to its anticancer properties, podophyllotoxone has also been investigated for its antiviral effects, particularly against certain viral infections. It is a white to off-white crystalline solid, and its solubility varies in different solvents. Due to its potent biological effects, podophyllotoxone is handled with care in laboratory settings, and its use is subject to regulatory oversight.

Formula: C₂₂H₂₀O₈

InChI: InChI=1S/C22H20O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-19H,8-9H2,1-3H3/t13-,18+,19-/m0/s1

InChI key: InChIKey=ISCQYPPCSYRZOT-BKTGTZMESA-N

SMILES: O=C1[C@@]2([C@@H](C=3C(C(=O)[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(OC)C(OC)=C5)[H]

Synonyms:

• (5aR,8aR,9R)-5a,6,8a,9-Tetrahydro-9-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione, 5a,6,8a,9-tetrahydro-9-(3,4,5-trimethoxyphenyl)-, (5aR,8aR,9R)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione, 5a,6,8a,9-tetrahydro-9-(3,4,5-trimethoxyphenyl)-, [5aR-(5aα,8aβ,9α)]-
• Podophyllotoxinone
• Podophyllotoxone
• furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione, 5a,6,8a,9-tetrahydro-9-(3,4,5-trimethoxyphenyl)-, (5aR,8aR,9R)-

Podophyllotoxone

CAS: 477-49-6

Podophyllotoxone

Purity: ≥98%

Molecular weight: 412.39g/mol

Ref: 54-BUP11446

Podophyllotoxone

CAS: 477-49-6

Formula: C₂₂H₂₀O₈

Purity: 95%~99%

Molecular weight: 412.394

Ref: BP-BP4524

Podophyllotoxone

CAS: 477-49-6

Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.

Formula: C₂₂H₂₀O₈

Purity: 99.31% - 99.37%

Color and Shape: Solid

Molecular weight: 412.39

Ref: TM-T8188

Podophyllotoxin EP Impurity C (Podophyllotoxone)

CAS: 477-49-6

Formula: C₂₂H₂₀O₈

Molecular weight: 412.39

Ref: 4Z-P-122004

Etoposide Impurity 8

CAS: 477-49-6

Formula: C₂₂H₂₀O₈

Molecular weight: 412.39

Ref: ST-EA-CP-E31026

Podophyllotoxone

Controlled Product

CAS: 477-49-6

Formula: C₂₂H₂₀O₈

Color and Shape: Neat

Molecular weight: 412.389

Ref: TR-P681020

Podophyllotoxone

CAS: 477-49-6

Podophyllotoxone is a potent antimitotic compound derived from the rhizomes and roots of the Podophyllum plant, predominantly Podophyllum peltatum and Podophyllum hexandrum. It functions primarily by binding to and destabilizing microtubules, which are essential components of the cell division process. This action hinders the polymerization of tubulin, effectively arresting cells in the metaphase of mitosis, leading to the inhibition of cellular proliferation.

Formula: C₂₂H₂₀O₈

Purity: Min. 95%

Molecular weight: 412.39 g/mol

Ref: 3D-XP161642