CAS 477-58-7

Tubocurine

Description:

Tubocurine is a chemical compound classified as a neuromuscular blocking agent, primarily derived from the plant Chondrodendron tomentosum. It is known for its ability to induce muscle paralysis by blocking the transmission of nerve impulses at the neuromuscular junction, specifically by antagonizing the action of acetylcholine at nicotinic receptors. Tubocurine is a quaternary ammonium compound, which contributes to its pharmacological properties and limits its ability to cross the blood-brain barrier, resulting in minimal central nervous system effects. The compound is typically administered intravenously and is used in clinical settings to facilitate surgical procedures by providing muscle relaxation. Its onset of action and duration of effect can vary based on dosage and individual patient factors. However, due to the development of newer neuromuscular blockers with more favorable pharmacokinetic profiles, the clinical use of tubocurine has diminished over time. Safety considerations include monitoring for potential side effects such as hypotension and respiratory depression, necessitating careful administration by trained healthcare professionals.

Formula: C₃₆H₃₈N₂O₆

InChI: InChI=1S/C36H38N2O6/c1-37-13-11-23-18-31(41-3)32-20-26(23)27(37)15-21-5-8-25(9-6-21)43-36-34-24(19-33(42-4)35(36)40)12-14-38(2)28(34)16-22-7-10-29(39)30(17-22)44-32/h5-10,17-20,27-28,39-40H,11-16H2,1-4H3/t27-,28+/m0/s1

InChI key: InChIKey=NGZXDRGWBULKFA-WUFINQPMSA-N

SMILES: OC1=C2C=3[C@@](CC=4C=C(OC=5C=C6[C@](CC=7C=CC(O2)=CC7)(N(C)CCC6=CC5OC)[H])C(O)=CC4)(N(C)CCC3C=C1OC)[H]

Synonyms:

• Chondrocurine
• 2′-Demethyltubocurarine
• Tubocuraran-7',12'-diol, 6,6'-dimethoxy-2,2'-dimethyl-
• Chondocurine
• Tubocuraran-7′,12′-diol, 6,6′-dimethoxy-2,2′-dimethyl-
• Chondrocurine
• 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline-9,19-diol, 2,3,13a,14,15,16,25,25a-octahydro-18,29-dimethoxy-1,14-dimethyl-, (13aR,25aS)-
• 6,6'-dimethoxy-2,2'-dimethyltubocuraran-7',12'-diol
• (13aR,25aS)-2,3,13a,14,15,16,25,25a-Octahydro-18,29-dimethoxy-1,14-dimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline-9,19-diol

Chondrocurine

CAS: 477-58-7

Chondrocurine is a biochemical that Inhibits quick death of mice treated with bacillus Calmetta Guerin & elicited with lipopolysaccharide.

Formula: C₃₆H₃₈N₂O₆

Color and Shape: Solid

Molecular weight: 594.7

Ref: TM-T69210