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CAS 477546-27-3

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  • NLRP3-IN-78
    Targetmol
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    NLRP3-IN-78

    CAS:
    <p>NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.</p>
    Formula:C12H5Cl2N3O4S2
    Color and Shape:Solid
    Molecular weight:390.222

    Ref: TM-T206735