CAS 477575-56-7: (3Z)-5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

Description: The chemical substance with the name "(3Z)-5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one" and CAS number "477575-56-7" is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups such as sulfonyl, carbonyl, and various aromatic rings. This compound is likely to exhibit significant biological activity, potentially serving as a pharmaceutical agent or a lead compound in drug development. Its structure suggests it may interact with specific biological targets, possibly influencing pathways related to neurological or metabolic functions. The presence of dichlorophenyl and pyrrolidine moieties indicates potential for lipophilicity, which can affect its pharmacokinetics and bioavailability. Additionally, the stereochemistry indicated by the (2R) and (3Z) designations suggests that the compound may exhibit chirality, which can influence its biological interactions and efficacy. Overall, this compound represents a class of molecules that may have therapeutic applications, warranting further investigation into its properties and effects.

Formula: C₃₂H₃₄Cl₂N₄O₄S

InChI: InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1

InChI key: InChIKey=OYONTEXKYJZFHA-SSHUPFPWSA-N

SMILES: O=C1NC2=CC=C(C=C2C1=CC=3NC(=C(C(=O)N4CCCC4CN5CCCC5)C3C)C)S(=O)(=O)CC=6C(Cl)=CC=CC6Cl

Synonyms:

• (2R)-1-[[5-[(z)-[5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3h-indol-3-ylidene]methyl]-2,4-dimethyl-1h-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
• (3Z)-5-[(2,6-Dichlorobenzyl)sulfonyl]-3-[(3,5-dimethyl-4-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
• (3Z)-5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one
• 2H-Indol-2-one, 5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-, (3Z)-
• Pha 665752
• Pha665752
• Pyrrolidine, 1-[[5-[(Z)-[5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)-, (2R)-
• Tcmdc-125885

PHA-665752

CAS: 477575-56-7

• Formula: C₃₂H₃₄Cl₂N₄O₄S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 641.6078

PHA-665752

CAS: 477575-56-7

• Purity: 99.35%
• Molecular weight: 641.61g/mol

PHA-665752 hydrate

CAS: 477575-56-7

• Formula: C₃₂H₃₄Cl₂N₄O₄S·xH₂O
• Molecular weight: 641.61 (anhydrous)

PHA-665752

CAS: 477575-56-7

• Molecular weight: 641.61g/mol

PHA-665752

CAS: 477575-56-7

PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for …

• Formula: C₃₂H₃₄Cl₂N₄O₄S
• Purity: 97.01% - 99.35%
• Color and Shape: Solid
• Molecular weight: 641.61

PHA-665752-d8 Hydrate

CAS: 477575-56-7

• Formula: C₃₂H₂₆D₈Cl₂N₄O₄S•xH₂O
• Color and Shape: Neat
• Molecular weight: 667.68

PHA-665752 Hydrate

CAS: 477575-56-7

• Formula: C₃₂H₃₄Cl₂N₄O₄S
• Color and Shape: Neat
• Molecular weight: 641.608

PHA 665752

CAS: 477575-56-7

Inhibitor of c-Met tyrosine kinase

• Formula: C₃₂H₃₄Cl₂N₄O₄S
• Purity: Min. 95%
• Molecular weight: 641.61 g/mol