CAS 477575-56-7

(3Z)-5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one

Description:

The chemical substance with the name "(3Z)-5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one" and CAS number "477575-56-7" is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups such as sulfonyl, carbonyl, and various aromatic rings. This compound is likely to exhibit significant biological activity, potentially serving as a pharmaceutical agent or a lead compound in drug development. Its structure suggests it may interact with specific biological targets, possibly influencing pathways related to neurological or metabolic functions. The presence of dichlorophenyl and pyrrolidine moieties indicates potential for lipophilicity, which can affect its pharmacokinetics and bioavailability. Additionally, the stereochemistry indicated by the (2R) and (3Z) designations suggests that the compound may exhibit chirality, which can influence its biological interactions and efficacy. Overall, this compound represents a class of molecules that may have therapeutic applications, warranting further investigation into its properties and effects.

Formula: C₃₂H₃₄Cl₂N₄O₄S

InChI: InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1

InChI key: InChIKey=OYONTEXKYJZFHA-SSHUPFPWSA-N

SMILES: C(=C\1/C=2C(NC1=O)=CC=C(S(CC3=C(Cl)C=CC=C3Cl)(=O)=O)C2)\C4=C(C)C(C(=O)N5[C@@H](CN6CCCC6)CCC5)=C(C)N4

Synonyms:

• (2R)-1-[[5-[(z)-[5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3h-indol-3-ylidene]methyl]-2,4-dimethyl-1h-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
• (3Z)-5-[(2,6-Dichlorobenzyl)sulfonyl]-3-[(3,5-dimethyl-4-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
• (3Z)-5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one
• 2H-Indol-2-one, 5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-, (3Z)-
• Pha 665752
• Pha665752
• Pyrrolidine, 1-[[5-[(Z)-[5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)-, (2R)-
• Tcmdc-125885

PHA-665752

CAS: 477575-56-7

Formula: C₃₂H₃₄Cl₂N₄O₄S

Purity: 99%

Color and Shape: Solid

Molecular weight: 641.6078

Ref: IN-DA00DB78

PHA-665752

CAS: 477575-56-7

PHA-665752

Purity: ≥95%

Molecular weight: 641.61g/mol

Ref: 54-BUP13288

PHA-665752 hydrate

CAS: 477575-56-7

Formula: C₃₂H₃₄Cl₂N₄O₄S·xH₂O

Molecular weight: 641.61 (anhydrous)

Ref: 7W-GL1966

PHA-665752

CAS: 477575-56-7

PHA-665752

Purity: 99%

Molecular weight: 641.61g/mol

Ref: 54-OR1023807

PHA-665752

CAS: 477575-56-7

PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.

Formula: C₃₂H₃₄Cl₂N₄O₄S

Purity: 97.05% - 98.82%

Color and Shape: Solid

Molecular weight: 641.61

Ref: TM-T6128

PHA-665752-d8 Hydrate

Controlled Product

CAS: 477575-56-7

Formula: C₃₂H₂₆D₈Cl₂N₄O₄S•xH₂O

Color and Shape: Neat

Molecular weight: 667.68

Ref: TR-P294427

PHA-665752 Hydrate

Controlled Product

CAS: 477575-56-7

Formula: C₃₂H₃₄Cl₂N₄O₄S

Color and Shape: Neat

Molecular weight: 641.608

Ref: TR-P294425

PHA 665752

CAS: 477575-56-7

Inhibitor of c-Met tyrosine kinase

Formula: C₃₂H₃₄Cl₂N₄O₄S

Purity: Min. 95%

Molecular weight: 641.61 g/mol

Ref: 3D-FP71590