CAS 477600-75-2: Tofacitinib

Description: Tofacitinib is a small molecule drug classified as a Janus kinase (JAK) inhibitor, primarily used in the treatment of autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Its chemical formula is C16H20N6O, and it has a molecular weight of approximately 312.37 g/mol. Tofacitinib works by selectively inhibiting the activity of JAK enzymes, which play a crucial role in the signaling pathways of various cytokines involved in immune responses. This inhibition helps to reduce inflammation and modulate the immune system. The substance is typically administered orally and is known for its relatively rapid onset of action. Tofacitinib's pharmacokinetics include good oral bioavailability, with metabolism primarily occurring in the liver via cytochrome P450 enzymes. Common side effects may include infections, elevated liver enzymes, and changes in blood cell counts, necessitating regular monitoring during treatment. Overall, Tofacitinib represents a significant advancement in targeted therapy for chronic inflammatory conditions.

Formula: C₁₆H₂₀N₆O

InChI: InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1

InChI key: InChIKey=UJLAWZDWDVHWOW-YPMHNXCESA-N

SMILES: N#CCC(=O)N1CCC(C)C(N(C=2N=CN=C3NC=CC32)C)C1

Synonyms:

• (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile
• 1-Piperidinepropanenitrile, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, (3R,4R)-
• 3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
• 3-Piperidinamine, 1-(cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-, (3R,4R)-
• 3-{(3S,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
• Cp 690550
• Tofacitinib

3-[(3S,4S)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile

CAS: 477600-75-2

• Formula: C₁₆H₂₀N₆O
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 312.3696

Tofacitinib

CAS: 477600-75-2

• Purity: ≥98%
• Molecular weight: 312.37g/mol

Tofacitinib

CAS: 477600-75-2

• Formula: C₁₆H₂₀N₆O
• Purity: ≥ 98.0%
• Color and Shape: White to off-white solid
• Molecular weight: 312.37

Tofacitinib

CAS: 477600-75-2

Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of …

• Formula: C₁₆H₂₀N₆O
• Purity: 100% - 99.71%
• Color and Shape: Solid
• Molecular weight: 312.37

Tofacitinib

CAS: 477600-75-2

JAK3 enzyme inhibitor

• Formula: C₁₆H₂₀N₆O
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 312.37 g/mol