CAS 4781-83-3

2-iminothiolane hydrochloride

Description:

2-Iminothiolane hydrochloride, also known as thiolane or a derivative of thiolane, is a chemical compound characterized by its unique structure that includes a thiol group (-SH) and an imine functional group (C=N). This compound is typically presented as a white to off-white solid and is soluble in water and various organic solvents, making it versatile for laboratory applications. It is primarily used in bioconjugation processes, particularly in the modification of biomolecules such as proteins and peptides, due to its ability to form stable thioether bonds with sulfhydryl groups. The hydrochloride form indicates that it is a salt, which can enhance its stability and solubility. Additionally, 2-iminothiolane hydrochloride is known for its reactivity, particularly in the presence of nucleophiles, which makes it valuable in synthetic organic chemistry and biochemistry. Safety precautions should be observed when handling this compound, as it may pose health risks if ingested or inhaled.

Formula: C₄H₇NS

InChI: InChI=1/C4H7NS/c5-4-2-1-3-6-4/h5H,1-3H2

InChI key: InChIKey=ATGUDZODTABURZ-UHFFFAOYSA-N

SMILES: N=C1CCCS1.Cl

Synonyms:

• (2Z)-dihydrothiophen-2(3H)-imine
• 2(3H)-Thiophenimine, dihydro-, hydrochloride
• 2(3H)-Thiophenimine, dihydro-, hydrochloride (1:1)
• Methyl-4-mercaptobutyrimidate hydrochloride 2-Iminothiolane hydrochloride
• Traut's reagent
• dihydrothiophen-2(3H)-imine
• 2-Iminothiolane hydrochloride
• 2-Iminothiolane, Hydrochloride
• METHYL 4-MERCAPTOBUTYRIMIDATE HYDROCHLORIDE
• 2-IMINOTHIOLANE HCL
• 2-THIOLANIMINE HYDROCHLORIDE
• 2-Furancarboxyaldehyde, Reagent
• DIHYDRO-2(3H)-THIOPHENIMINE HYDROCHLORIDE
• 2-IMINOTHIOLANE

2-Iminothiolane hydrochloride

CAS: 4781-83-3

Protein modification and cross-linking reagent, cleavable by thiols

Formula: C₄H₈ClNS

Color and Shape: Powder, White

Molecular weight: 137.63

Ref: 02-J60131

2-Iminothiolane

CAS: 4781-83-3

Formula: C₄H₈ClNS

Purity: 95%

Color and Shape: Solid

Molecular weight: 137.6310

Ref: IN-DA00DAFB

2-Iminothiolane hydrochloride

CAS: 4781-83-3

2-Iminothiolane hydrochloride

Formula: C₄H₇NS·ClH

Purity: 95%

Color and Shape: white solid

Molecular weight: 137.63g/mol

Ref: 54-BIM099

2-Iminothiolane HCl

CAS: 4781-83-3

2-Iminothiolane HCl

Purity: ≥98%

Molecular weight: 137.63g/mol

Ref: 54-BUP14469

2-Iminothiolane Hydrochloride

CAS: 4781-83-3

Formula: C₄H₇NS·HCl

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 137.63

Ref: 3B-I0820

2-Iminothiolane, Hydrochloride

Controlled Product

CAS: 4781-83-3

Applications A valuable tool in studies of cellular organelles and oligomeric enzymes, using the techniques of protein-protein cross-linking. It may also be used to introduce reactive sulfhydryl groups into proteins for subsequent reaction with alkylating agents or heavy metal compounds.
References Perham, R.N. & Thomas, J.O.: J. Mol. Biol., 62, 415 (1971), Jue, R., et al: Biochemistry, 17, 5399 (1978)

Formula: C₄H₇NS·ClH

Color and Shape: Neat

Molecular weight: 137.63

Ref: TR-I450000

2-Iminothiolane hydrochloride

CAS: 4781-83-3

Formula: C₄H₈ClNS

Purity: 95%

Color and Shape: Solid

Molecular weight: 137.63

Ref: 10-F492562

2-Iminothiolane HCl

CAS: 4781-83-3

2-Iminothiolane HCl (Trauts reagent) is a useful RNA-protein crosslinking reagent and an effective thiolation reagent for the introduction of sulphydryl groups

Formula: C₄H₈ClNS

Purity: 98.08% - 98.52%

Color and Shape: Solid

Molecular weight: 137.63

Ref: TM-T19958

2-Iminothiolane hydrochloride

CAS: 4781-83-3

2-Iminothiolane hydrochloride is an amine that reacts with free thiol groups in proteins. It can be used to generate models of protein structures, as well as to study the effects of disulfide bonds on protein stability and function. 2-Iminothiolane hydrochloride has been shown to inhibit HIV infection by blocking the uptake of all-trans retinoic acid into cells. This drug also has minimal toxicity and can be used for cancer therapy. The drug was shown to have minimal toxicity in vitro, but it has not yet been tested in vivo.

Formula: C₄H₈ClNS

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 137.63 g/mol

Ref: 3D-FI24559