CAS 479-43-6

Canthin-6-one

Description:

Canthin-6-one is an organic compound belonging to the class of alkaloids, specifically derived from the canthin family. It is characterized by a fused tetracyclic structure that includes a quinoline moiety. The compound typically exhibits a yellowish to brownish color and is known for its complex aromatic system, which contributes to its biological activity. Canthin-6-one has garnered interest in medicinal chemistry due to its potential pharmacological properties, including antimicrobial, anticancer, and anti-inflammatory activities. Its molecular formula reflects a specific arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, which influences its reactivity and interactions with biological systems. The compound is often studied for its role in traditional medicine and its potential applications in drug development. Additionally, its solubility characteristics can vary, affecting its bioavailability and efficacy in therapeutic contexts. Overall, Canthin-6-one represents a significant subject of research within the field of natural products and medicinal chemistry.

Formula: C₁₄H₈N₂O

InChI: InChI=1S/C14H8N2O/c17-13-6-5-11-14-10(7-8-15-11)9-3-1-2-4-12(9)16(13)14/h1-8H

InChI key: InChIKey=ZERVJPYNQLONEK-UHFFFAOYSA-N

SMILES: O=C1N2C=3C(C=4C2=CC=CC4)=CC=NC3C=C1

Synonyms:

• Canthin-6-one
• NSC 103003
• 6H-Indolo[3,2,1-de][1,5]naphthyridin-6-one

Canthin-6-one

CAS: 479-43-6

Formula: C₁₄H₈N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 220.2261

Ref: IN-DA00DDCV

Canthin-6-one

CAS: 479-43-6

Canthin-6-one

Purity: ≥98%

Molecular weight: 220.23g/mol

Ref: 54-BUP00236

Canthin-6-one

CAS: 479-43-6

Canthin-6-one (NSC 103003)is an alkaloid isolated from Allium neapolitanum with antibacterial activity and inhibitory effect against Mycobacterium tuberculosis.

Formula: C₁₄H₈N₂O

Purity: 99.10%

Color and Shape: Solid

Molecular weight: 220.23

Ref: TM-TN1466

Canthin-6-one

CAS: 479-43-6

Formula: C₁₄H₈N₂O

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 220.231

Ref: BP-SBP00061

Canthin-6-one

Controlled Product

CAS: 479-43-6

Applications Canthin-6-one is used as an anticancer agent compromising cancer cells showing multi-drug resistance. Also used in the synthesis of β-carbolinium compounds as antimalarial agents.
References Murakami, C. et al.: Bioorg. Med. Chem., 12, 4963 (2004); Takasu, K. et al.: Chem. Pharm. Bull., 53, 653 (2005);

Formula: C₁₄H₈N₂O

Color and Shape: Neat

Molecular weight: 220.23

Ref: TR-C175635

Canthin-6-one

CAS: 479-43-6

Canthin-6-one is a monoterpenoid indole alkaloid that has been shown to inhibit transcription. The natural compound does not exhibit any antimicrobial activity, but has been shown to be effective in the treatment of inflammatory bowel disease. Canthin-6-one binds to and inhibits bacterial DNA gyrase, preventing the replication of DNA. This compound also suppresses the production of proinflammatory cytokines such as IL-1β, IL-6 and TNFα from macrophages. Canthin-6-one has also been shown to have matrix effects on mass spectroscopy methods, such as liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS).

Formula: C₁₄H₈N₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 220.23 g/mol

Ref: 3D-AAA47943