CAS 479073-82-0

Hydroxythiohomosildenafil

Description:

Hydroxythiohomosildenafil, identified by the CAS number 479073-82-0, is a chemical compound that belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors. It is structurally related to sildenafil, a well-known medication used primarily for the treatment of erectile dysfunction and pulmonary arterial hypertension. The compound features a hydroxy group and a thioether moiety, which contribute to its pharmacological properties. Hydroxythiohomosildenafil is characterized by its ability to enhance blood flow by inhibiting the breakdown of cyclic guanosine monophosphate (cGMP), leading to vasodilation. This mechanism of action is similar to that of other PDE5 inhibitors. The compound may exhibit varying degrees of potency and selectivity compared to its analogs, and its safety profile and therapeutic applications are subjects of ongoing research. As with any pharmaceutical agent, understanding its pharmacokinetics, potential side effects, and interactions with other medications is crucial for its clinical use.

Formula: C₂₃H₃₂N₆O₄S₂

InChI: InChI=1S/C23H32N6O4S2/c1-4-6-18-20-21(27(3)26-18)23(34)25-22(24-20)17-15-16(7-8-19(17)33-5-2)35(31,32)29-11-9-28(10-12-29)13-14-30/h7-8,15,30H,4-6,9-14H2,1-3H3,(H,24,25,34)

InChI key: InChIKey=XZVSAQIQEGFWQS-UHFFFAOYSA-N

SMILES: O(CC)C1=C(C=C(S(=O)(=O)N2CCN(CCO)CC2)C=C1)C=3NC4=C(C(=S)N3)N(C)N=C4CCC

Synonyms:

• 1-Piperazineethanol, 4-[[3-(4,7-dihydro-1-methyl-3-propyl-7-thioxo-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-
• Hydroxythiohomosildenafil
• 5-(2-ethoxy-5-(4-(2-hydroxyethyl)piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-thione
• 7H-Pyrazolo[4,3-d]pyrimidine-7-thione, 5-[2-ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-
• 5-[2-Ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidine-7-thione

Hydroxythiohomo Sildenafil

CAS: 479073-82-0

Formula: C₂₃H₃₂N₆O₄S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 520.6680

Ref: IN-DA006YFE

Hydroxythiohomo Sildenafil

CAS: 479073-82-0

Formula: C₂₃H₃₂N₆O₄S₂

Color and Shape: Pale Yellow Solid

Molecular weight: 520.67

Ref: 4Z-S-0611

Hydroxythiohomosildenafil

CAS: 479073-82-0

Hydroxythiohomosildenafil

Purity: ≥98%

Molecular weight: 520.67g/mol

Ref: 54-BUP03342

Hydroxythiohomo Sildenafil

CAS: 479073-82-0

Applications Hydroxythiohomo Sildenafil is a Sildenafil thiono analog, a novel pyrazolopyrimidinethione with PDE5 inhibiting properties.
References Koh, H.L. and Woo, S.O. 2000. Drug Saf. 23: 351-362; Seftel, A.D., 2004. Clin Cardiol. 27: I14-I19; Bednar, M.M. 2008. Curr Opin Investig Drugs. 9: 754-759.

Formula: C₂₃H₃₂N₆O₄S₂

Color and Shape: Neat

Molecular weight: 520.67

Ref: TR-H963150

Hydroxythiohomo sildenafil

CAS: 479073-82-0

Hydroxythiohomo sildenafil is a pharmaceutical drug that belongs to the class of PDE-5 inhibitors. It is a metabolite of sildenafil and has been shown to have similar effects as its parent compound, but with improved absorption. This drug inhibits the breakdown of cGMP by phosphodiesterase type 5 (PDE-5) in the corpus cavernosum, leading to an increase in penile erection. Hydroxythiohomo sildenafil has been shown to improve erectile function in people with diabetes mellitus and appears to be effective for treating erectile dysfunction. Hydroxythiohomo sildenafil is currently under development for the treatment of pulmonary arterial hypertension.

Formula: C₂₃H₃₂N₆O₄S₂

Purity: Min. 95%

Color and Shape: Slightly Yellow Powder

Molecular weight: 520.67 g/mol

Ref: 3D-FH24512

Hydroxythiohomosildenafil

CAS: 479073-82-0

Hydroxythiohomosildenafil, an analogue of sildenafil, is a phosphodiesterase-5 (PDE-5) inhibitor.

Formula: C₂₃H₃₂N₆O₄S₂

Purity: 99.45%

Color and Shape: Solid

Molecular weight: 520.67

Ref: TM-T25513

Hydroxythiohomo Sildenafil

CAS: 479073-82-0

Formula: C₂₃H₃₂N₆O₄S₂

Molecular weight: 520.67

Ref: ST-EA-CP-S2161