CAS 47931-85-1

Calcitonin (salmon)

Description:

Calcitonin (salmon) is a peptide hormone that plays a crucial role in calcium homeostasis and bone metabolism. It is derived from the salmon species, which has a more potent form compared to human calcitonin. This substance is composed of 32 amino acids and is known for its ability to lower blood calcium levels by inhibiting osteoclast activity, which reduces bone resorption. Calcitonin also promotes renal excretion of calcium and phosphate, further contributing to its hypocalcemic effects. It is commonly used in clinical settings for the treatment of conditions such as osteoporosis and Paget's disease. The CAS number 47931-85-1 uniquely identifies this specific formulation of calcitonin. In terms of physical properties, calcitonin (salmon) is typically administered via injection due to its peptide nature, which limits its bioavailability when taken orally. Its therapeutic effects are generally rapid, making it a valuable option in managing hypercalcemia and related disorders.

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

InChI: InChI=1/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)

SMILES: CC(C)CC(C(=NCC(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CO)C(=NC(CCC(=N)O)C(=NC(CCC(=O)O)C(=NC(CC(C)C)C(=NC(Cc1cnc[nH]1)C(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CCC(=N)O)C(=NC(C(C)O)C(=NC(Cc1ccc(cc1)O)C(=O)N1CCCC1C(=NC(CCCNC(=N)N)C(=NC(C(C)O)C(=NC(CC(=N)O)C(=NC(C(C)O)C(=NCC(=NC(CO)C(=NCC(=NC(C(C)O)C(=O)N1CCCC1C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(C(C)C)N=C(C1CSSCC(C(=NC(CO)C(=NC(CC(=N)O)C(=NC(CC(C)C)C(=NC(CO)C(=NC(C(C)O)C(=N1)O)O)O)O)O)O)N)O)O

Synonyms:

• Calcitonin (salmon I)
• Thyrocalcitonin Salmon
• H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bond)
• Thyrocalcitonin
• Salmon calcitonin
• Salcitonin
• Salmon Calcitonin acetate
• Salmon
• Calcitonin salmon Acetate
• Calciben
• Calcimar
• Calcitonin (Lachs)
• Calcitonin (salmon reduced) cyclic (1→7)-disulfide
• Calcitonina (Salmon)
• Calcitonine (Saumon)
• Calsyn
• Calsynar
• Catonin
• Karil
• L-Prolinamide, L-cysteinyl-L-seryl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-, cyclic (1→7)-disulfide
• Miacalcic
• Miacalcin
• Miadenil
• Prontocalcin
• Rulicalcin
• Salcatonin
• Salmon calcitonin I
• Salmon calcitonin-(1-32)
• Salmon Thyrocalcitonin
• Salmotonin
• Stalcin
• Tonocalcin
• Calcitonin(Salmone) Acetate

Calcitonin (salmon I)

CAS: 47931-85-1

Calcitonin inhibits osteoclast activity, lowers the blood calcium level, and positively influences bone mass density. Salmon calcitonin (sCT) is more potent than the human analog. sCT may act as an amylin agonist (Wielinga et al.). In animal studies, administration of sCT was shown to reduce food intake.

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Purity: 99.3%

Color and Shape: White Lyophilisate

Molecular weight: 3431.9

Ref: 01-4033011

CALCITONIN-GLY CRS

CAS: 115472-96-3, 47931-85-1

CALCITONIN-GLY CRS

Ref: 41-Y0000632

CALCITONIN (SALMON) CRS

CAS: 47931-85-1

CALCITONIN (SALMON) CRS

Formula: C₈H₆BrN

Molecular weight: 196.0439

Ref: 41-C0200000

Calcitonin Salmon

CAS: 47931-85-1

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Color and Shape: White Off-White Powder

Molecular weight: 3429.71331

Ref: 45-1086200

Calcitonin (Salmon)

CAS: 47931-85-1

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Molecular weight: 3431.90

Ref: 4Z-PC-322001

Calcitonin Salmon

CAS: 47931-85-1

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Purity: >95.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 3,431.90

Ref: 3B-C3597

Calcitonin (salmon)

CAS: 47931-85-1

Calcitonin (salmon), a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Purity: 99.41% - 99.80%

Color and Shape: Powder

Molecular weight: 3431.85

Ref: TM-TP1040

Calcitonin Acetate(Salmon)

CAS: 47931-85-1

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 3431.85

Ref: BP-BPPG013

Calcitonin Salmon RS

CAS: 47931-85-1, 5989-81-1

Color and Shape: White Solid

Ref: 2K-1039500021

Calcitonin, Salmon

CAS: 47931-85-1

Applications Calcitonin, Salmon is a calcium regulating hormone which exhibits hypocalcaemic and hypophosphatemic properties.

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Color and Shape: Neat

Molecular weight: 3431.85

Ref: TR-C144558

N-Acetyl-cys(1)-calcitonin Salmon Trifluoroacetic Acid Salt

Controlled Product

CAS: 47931-85-1

Applications N-Acetyl-cys(1)-calcitonin Salmon is a derivative of Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
References Boron, WF., et al.: Med. Physi., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);

Formula: C₁₄₇H₂₄₃N₄₄O₄₉S₂·x(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 3475.5911402

Ref: TR-A168465

Calcitonin (salmon) xAcetate

Controlled Product

CAS: 47931-85-1

Applications Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
References Boron, WF. et al.: Med. Phys., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂·x(CH₃CO₂H)

Color and Shape: Neat

Molecular weight: 3431.856005

Ref: TR-C144555

Calcitonin

CAS: 47931-85-1

Calcitonin is a peptide hormone that inhibits the release of calcium from bone, and decreases the blood level of calcium. Calcitonin is not active in the absence of parathyroid hormone (PTH) or vitamin D. It has been shown to inhibit the development of experimental myocardial infarcts in rats by inhibiting the release of calcium from bone, and has also been shown to have a protective effect on brain function. The calcitonin receptor is activated by binding with calcitonin, which then activates adenylyl cyclase and increases intracellular cAMP levels. This leads to increased activity at ATP-sensitive potassium channels, which causes hyperpolarisation of neurons. Caudate putamen neurons are particularly sensitive to calcitonin activity because they are rich in voltage-gated K+ channels that are sensitive to ATP-sensitive potassium channel activation. Calcitonin also plays a role in regulating serum Ca2+ concentration by inhib

Formula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Purity: Min. 95%

Molecular weight: 3,431.86 g/mol

Ref: 3D-FC36651

Calcitonin (salmon)

CAS: 47931-85-1

Calcitonin (salmon)

Color and Shape: White Powder

Ref: 47-355