CAS 480-85-3

Retronecine

Description:

Retronecine is a naturally occurring alkaloid that belongs to the class of pyrrolizidine alkaloids, which are known for their complex bicyclic structure. It is primarily derived from various plant species, particularly those in the Boraginaceae family. Retronecine is characterized by its molecular formula, which includes a nitrogen atom in its structure, contributing to its classification as an alkaloid. This compound is notable for its potential toxicity, as many pyrrolizidine alkaloids can be hepatotoxic and carcinogenic upon metabolic activation in the liver. Retronecine is often studied for its biological effects, including its impact on cellular processes and its role in plant defense mechanisms. In terms of physical properties, retronecine is typically a colorless to pale yellow liquid or solid, depending on its form, and it has a relatively low solubility in water but is more soluble in organic solvents. Due to its toxicological profile, handling retronecine requires caution, and it is subject to regulatory scrutiny in various applications, particularly in herbal medicine and food safety.

Formula: C₈H₁₃NO₂

InChI: InChI=1/C8H13NO2/c10-5-6-1-3-9-4-2-7(11)8(6)9/h1,7-8,10-11H,2-5H2/t7-,8-/m1/s1

InChI key: InChIKey=HJSJELVDQOXCHO-HTQZYQBOSA-N

SMILES: C(O)C=1[C@]2(N(CC1)CC[C@H]2O)[H]

Synonyms:

• (1R,7aR)-2,3,5,7a-Tetrahydro-1-hydroxy-1H-pyrrolizine-7-methanol
• (1R,7aR)-7-(hydroxymethyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-ol
• 1H-Pyrrolizine-7-methanol, 2,3,5,7a-beta-tetrahydro-1-alpha-hydroxy-
• 1H-Pyrrolizine-7-methanol, 2,3,5,7a-tetrahydro-1-hydroxy-, (1R,7aR)-
• 1H-Pyrrolizine-7-methanol, 2,3,5,7a-tetrahydro-1-hydroxy-, (1R-trans)-
• 1H-Pyrrolizine-7-methanol, 2,3,5,7a-tetrahydro-1-hydroxy-, (1R-trans)- (9CI)
• Ccris 5776
• Hsdb 3567
• Retronecin
• Senecifolinene
• Retronecine
• (+)-Retronecine
• ( )-Retronecine
• (1R)-2,3,5,7aβ-Tetrahydro-1α-hydroxy-1H-pyrrolizine-7-methanol

Retronecine

CAS: 480-85-3

Retronecine acts as the better competitor for the competitive inhibition of antibodies to Retronecine.

Formula: C₈H₁₃NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 155.20

Ref: TM-TN2145

Retronecine

CAS: 480-85-3

Formula: C₈H₁₃NO₂

Molecular weight: 155.20

Ref: 4Z-R-134001

Retronecine-d3

CAS: 480-85-3

Formula: C₈H₁₀D₃NO₂

Molecular weight: 158.22

Ref: 4Z-R-134002

Retronecine

CAS: 480-85-3

Natural alkaloid

Formula: C₈H₁₃NO₂

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 155.19

Ref: 5G-83901

(+)-Retronecine

CAS: 480-85-3

Applications (+)-Retronecine, is a Pyrrolizidine alkaloid (PA) , which is a hepatotoxic, that is, damaging to the liver. It is also tumorigenic. It can also be used as an intermediate for the synthesis of (+)-Lycopsamine (L487525), and (E325580).
References Qingsu, X., et al.: Chem. Res. Toxic., 26, 1384 (2013); Bosi,, C. F., et al.: Revista Brasileira de Farmacognosia, 23, 425 (2013);

Formula: C₈H₁₃NO₂

Color and Shape: Neat

Molecular weight: 155.19

Ref: TR-R278000