CAS 4803-88-7

Cytidine, 5'-azido-2',5'-dideoxy-

Description:

Cytidine, 5'-azido-2',5'-dideoxy- is a nucleoside analog characterized by the presence of an azido group at the 5' position and lacking the 2' and 3' hydroxyl groups typically found in ribonucleosides. This modification imparts unique properties, making it a subject of interest in biochemical and pharmaceutical research, particularly in the study of nucleic acid interactions and antiviral therapies. The absence of hydroxyl groups enhances its stability against nucleases, which can be advantageous in therapeutic applications. The azido group can also facilitate further chemical modifications or conjugation to other molecules, potentially leading to novel drug designs. As a dideoxynucleoside, it can interfere with DNA synthesis, making it a valuable tool in molecular biology for studying DNA replication and repair mechanisms. Its CAS number, 4803-88-7, allows for precise identification in chemical databases and literature. Overall, this compound exemplifies the strategic modifications used in nucleoside analogs to explore biological processes and develop therapeutic agents.

Formula: C₉H₁₂N₆O₃

5'-Azido-2',5'-dideoxycytidine

CAS: 4803-88-7

5'-Azido-2',5'-dideoxycytidine is a macrocyclic nucleoside that has been shown to be a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication. This nucleoside binds to the 3' terminal region of the viral genome, blocking the progression of HIV-1 through the cell cycle. 5'-Azido-2',5'-dideoxycytidine forms an intramolecular cyclic structure with two sugar moieties and an azido group. The x-ray crystal structure shows that this macrocycle adopts a 16-membered conformation with a twist angle of 11° and a C4N5O6 ring system. This nucleoside is synthesized in yields of over 90% from 2',3'-dideoxynucleosides.

Formula: C₉H₁₂N₆O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 252.23 g/mol

Ref: 3D-NA45440