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CAS 480449-71-6

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Edoxaban (TsOH salt)

Description:
Edoxaban (TsOH salt) is a chemical compound that serves as an anticoagulant, primarily used in the prevention and treatment of thromboembolic disorders. It is a direct factor Xa inhibitor, which means it works by selectively inhibiting the activity of factor Xa, an essential enzyme in the coagulation cascade, thereby reducing the formation of blood clots. The "TsOH" in its name refers to the tosylate salt form, which enhances its solubility and stability. Edoxaban is characterized by its relatively high bioavailability and a predictable pharmacokinetic profile, allowing for fixed dosing without the need for routine monitoring of anticoagulation levels. It is typically administered orally and has a half-life that supports once-daily dosing. The compound is also known for its favorable safety profile, with a lower risk of major bleeding compared to some traditional anticoagulants. As with any medication, it is essential to consider potential drug interactions and contraindications when prescribing Edoxaban.
Formula:C31H38ClN7O7S2
InChI:InChI=1S/C24H30ClN7O4S.C7H8O3S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23;1-6-2-4-7(5-3-6)11(8,9)10/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34);2-5H,1H3,(H,8,9,10)/t13-,15-,17+;/m0./s1
InChI key:InChIKey=ZLFZITWZOYXXAW-QXXZOGQOSA-N
SMILES:N(C(=O)C1=NC2=C(S1)CN(C)CC2)[C@H]3[C@@H](NC(C(NC4=CC=C(Cl)C=N4)=O)=O)CC[C@H](C(N(C)C)=O)C3.S(=O)(=O)(O)C1=CC=C(C)C=C1
Synonyms:
  • DU 176b
  • Edoxaban Tosylate
  • Ethanediamide, N-(5-chloro-2-pyridinyl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, mono(4-methylbenzenesulfonate)
  • Ethanediamide, N<sup>1</sup>-(5-chloro-2-pyridinyl)-N<sup>2</sup>-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate (1:1)
  • Lixiana
  • Roteas
  • Savaysa
  • Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate (1:1)
  • Edoxaban (TsOH salt)
  • Edoxaban TsOH
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