CAS 481658-94-0

Dirlotapide

Description:

Dirlotapide is a chemical compound primarily known for its application in veterinary medicine, specifically for the management of obesity in dogs. It functions as a selective inhibitor of the microsomal triglyceride transfer protein (MTP), which plays a crucial role in lipid metabolism. By inhibiting MTP, dirlotapide reduces the absorption of dietary fats and promotes weight loss in canines. The substance is typically administered orally and is characterized by its ability to alter lipid profiles and reduce body weight without significantly affecting lean body mass. Dirlotapide is also noted for its safety profile in dogs when used as directed, although potential side effects may include gastrointestinal disturbances. As a synthetic compound, it has a specific molecular structure that contributes to its pharmacological effects, and it is classified under the broader category of anti-obesity agents. Its development reflects ongoing efforts to address pet obesity, a growing concern in veterinary health.

Formula: C₄₀H₃₃F₃N₄O₃

InChI: InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1

InChI key: InChIKey=TUOSYWCFRFNJBS-BHVANESWSA-N

SMILES: CN1C=2C(C=C1C(N[C@H](C(N(CC3=CC=CC=C3)C)=O)C4=CC=CC=C4)=O)=CC(NC(=O)C5=C(C=CC=C5)C6=CC=C(C(F)(F)F)C=C6)=CC2

Synonyms:

• 1H-Indole-2-carboxamide, 1-methyl-N-[(1S)-2-[methyl(phenylmethyl)amino]-2-oxo-1-phenylethyl]-5-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-
• Dirlotapide
• Slentrol
• 1-Methyl-N-[(1S)-2-[methyl(phenylmethyl)amino]-2-oxo-1-phenylethyl]-5-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-1H-indole-2-carboxamide
• CP 742033

Dirlotapide

Controlled Product

CAS: 481658-94-0

Dirlotapide is a drug that is used to treat obesity and dyslipidemia. It is a diacylglycerol-lowering agent that can be used in the treatment of heart disease, inflammatory diseases, and other animal health problems. Dirlotapide has been shown to reduce levels of fatty acids and triglycerides. This drug also has protein-inhibiting properties, which are thought to be responsible for its ability to lower cholesterol levels by inhibiting the synthesis of apolipoprotein A1. Clinical studies have shown that dirlotapide can lead to insulin resistance, which may contribute to weight gain.

Formula: C₄₀H₃₃F₃N₄O₃

Purity: Min. 95%

Molecular weight: 674.7 g/mol

Ref: 3D-GUA65894

Dirlotapide

CAS: 481658-94-0

Dirlotapide (CP742033), an intestinal MTP inhibitor, cuts weight in diabetic dogs by lowering food intake and raising peptide YY.

Formula: C₄₀H₃₃F₃N₄O₃

Purity: 98.47% - 99.62%

Color and Shape: Solid

Molecular weight: 674.71

Ref: TM-T15006