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CAS 481681-02-1

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[4-fluoro-3-(hydroxymethyl)phenyl]boronic acid

Description:
[4-Fluoro-3-(hydroxymethyl)phenyl]boronic acid is an organoboron compound characterized by the presence of a boronic acid functional group, which is known for its ability to form reversible covalent bonds with diols and other nucleophiles. This compound features a phenyl ring substituted with a fluorine atom and a hydroxymethyl group, contributing to its unique reactivity and potential applications in organic synthesis and medicinal chemistry. The boronic acid moiety allows for participation in Suzuki-Miyaura cross-coupling reactions, making it valuable in the formation of carbon-carbon bonds. Additionally, the presence of the fluorine atom can enhance the compound's lipophilicity and influence its biological activity. The hydroxymethyl group may also serve as a site for further functionalization or modification. Overall, [4-fluoro-3-(hydroxymethyl)phenyl]boronic acid is a versatile building block in the development of pharmaceuticals and agrochemicals, with properties that facilitate its use in various chemical transformations.
Formula:C7H8BFO3
InChI:InChI=1/C7H8BFO3/c9-7-2-1-6(8(11)12)3-5(7)4-10/h1-3,10-12H,4H2
SMILES:c1cc(c(cc1B(O)O)CO)F
Synonyms:
  • boronic acid, B-[4-fluoro-3-(hydroxymethyl)phenyl]-
  • 4-Fluoro-3-(Hydroxymethyl)Benzeneboronic Acid
  • 4-Fluoro-3-hydroxyMethyl)phenylboronic acid
  • [4-Fluoro-3-(hydroxymethyl)phenyl]boronic acid
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