CAS 482-20-2

tylophorine

Description:

Tylophorine, with the CAS number 482-20-2, is an alkaloid derived from the plant Tylophora indica, which is known for its medicinal properties. This compound is characterized by its complex structure, featuring a bicyclic framework that includes a phenanthrene core. Tylophorine exhibits a range of biological activities, including anti-inflammatory and immunomodulatory effects, making it of interest in pharmacological research. It has been studied for its potential therapeutic applications, particularly in the treatment of respiratory conditions and certain cancers. The compound is typically found in a crystalline form and is soluble in organic solvents, but its solubility in water is limited. Due to its biological activity, tylophorine has garnered attention for its potential use in traditional medicine, although further research is needed to fully understand its mechanisms of action and therapeutic efficacy. Safety and toxicity profiles are also important considerations in its application, necessitating careful handling and further investigation in clinical settings.

Formula: C₂₄H₂₇NO₄

InChI: InChI=1/C24H27NO4/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2/h9-12,14H,5-8,13H2,1-4H3/t14-/m0/s1

InChI key: InChIKey=SSEUDFYBEOIWGF-AWEZNQCLSA-N

SMILES: O(C)C1=CC2=C3C(=C4C(=C2C=C1OC)C[C@]5(N(C4)CCC5)[H])C=C(OC)C(OC)=C3

Synonyms:

• (+)-(S)-Tylophorine
• (13aS)-2,3,6,7-tetramethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline
• (13aS)-9,11,12,13,13a,14-Hexahydro-2,3,6,7-tetramethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinoline
• (S)-9,11,12,13,13a,14-Hexahydro-2,3,6,7-tetramethoxydibenzo(f,h)pyrrolo(1,2-b)isoquinoline
• 2,3,6,7-Tetramethoxyphenanthro(9,10:6,7')indolizidine
• Dibenzo(f,h)pyrrolo(1,2-b)isoquinoline, 9,11,12,13,13a,14-hexahydro-2,3,6,7-tetramethoxy-, (S)- (9CI)
• Dibenzo[f,h]pyrrolo[1,2-b]isoquinoline, 9,11,12,13,13a,14-hexahydro-2,3,6,7-tetramethoxy-, (13aS)-
• Dibenzo[f,h]pyrrolo[1,2-b]isoquinoline, 9,11,12,13,13a,14-hexahydro-2,3,6,7-tetramethoxy-, (S)-
• NSC 717335
• Nsc 76387
• Nstp 0G01
• Tylophorin
• Tylophorine (8CI)
• Tylophorine
• 6,7,10,11-Tetramethoxy-2,3-trimethylene-1,2,3,4-tetrahydrodibenzo[f,h]isoquinoline
• (S)-9,11,12,13,13a,14-Hexahydro-2,3,6,7-tetramethoxydibenzo(f,h)pyrrol o(1,2-b)isoquinoline

Tylophorine

CAS: 482-20-2

Tylophorine, from Tylophora indica, has anti-inflammatory, antitumor effects, halts G1 phase in cancer cells by suppressing cyclin A2.

Formula: C₂₄H₂₇NO₄

Color and Shape: Solid

Molecular weight: 393.48

Ref: TM-T29026

(+)-(S)-Tylophorine

Controlled Product

CAS: 482-20-2

Applications (+)-(S)-Tylophorine is a a major alkaloid of Tylophora indica. (+)-(S)-Tylophorine is an immunosuppressant and inflammation inhibitor. (+)-(S)-Tylophorine showed antiproliferative activity and induction of apoptosis in tumor cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gopalakrishnan, C. et a.: Ind. J. Med. Chem., 71, 940 (1980); Ganguly, T.et al.: Phytomedicine, 9, 288 (2002); Gao, W. et al.: Cancer, Res., 64, 678 (2004);

Formula: C₂₄H₂₇NO₄

Color and Shape: Neat

Molecular weight: 393.48

Ref: TR-T898200