CAS 48237-20-3

AMikacin B

Description:

Amikacin B, identified by the CAS number 48237-20-3, is an aminoglycoside antibiotic derived from kanamycin. It is primarily used in clinical settings to treat infections caused by certain Gram-negative bacteria, particularly those resistant to other antibiotics. Amikacin B exhibits a broad spectrum of antibacterial activity, making it effective against various pathogens, including Pseudomonas aeruginosa and some strains of Enterobacteriaceae. The mechanism of action involves binding to the bacterial ribosome, inhibiting protein synthesis, which ultimately leads to cell death. This compound is typically administered via injection, as it is poorly absorbed from the gastrointestinal tract. Its pharmacokinetics include a relatively long half-life, allowing for less frequent dosing compared to other aminoglycosides. However, it is essential to monitor renal function during treatment due to potential nephrotoxicity and ototoxicity associated with aminoglycosides. Overall, Amikacin B is a critical option in the antibiotic arsenal, particularly for treating multidrug-resistant infections.

Formula: C₂₂H₄₄N₆O₁₂

Synonyms:

• Amikacin Impurity 8
• BB-K26
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-
• 1-N-[(S)-4-AMino-2-hydroxybutyryl]kanaMycin B
• O-3-AMino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diaMino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-aMino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptaMine
• AMikacin B

Amikacin EP Impurity H

CAS: 48237-20-3

Formula: C₂₂H₄₄N₆O₁₂

Molecular weight: 584.63

Ref: 4Z-A-144008

Amikacin B Sulfate

Controlled Product

CAS: 48237-20-3

Applications Amikacin (A578500) impurity, is a new aminoglycoside antibiotic.
References Jung, F., et al.: J. Med. Chem., 34, 1110 (1991}, Choi, K., et al.: J. Antimicrob. Chemother., 39, 509 (1997), Galimand, M., et al.: Antimicrob. Agents Chemother., 47, 2565 (2003),

Formula: C₂₂H₄₄N₆O₁₂·xH₂SO₄

Color and Shape: Neat

Molecular weight: 584.62 + x(98.07)

Ref: TR-A578515

Amikacin B Sulfate

CAS: 48237-20-3

Inhibitor of protein synthesis; aminoglycoside

Formula: C₂₂H₄₄N₆O₁₂xH₂so₄

Purity: Min. 95%

Molecular weight: 584.62 g/mol

Ref: 3D-AA17355

Amikacin EP Impurity H

CAS: 48237-20-3

Formula: C₂₂H₄₄N₆O₁₂

Molecular weight: 584.62

Ref: ST-EA-CP-A190008