CAS 4828-27-7

Clocortolone

Description:

Clocortolone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in dermatological applications. It is characterized by its ability to modulate the immune response and reduce inflammation, making it effective in treating various skin conditions such as eczema and dermatitis. Clocortolone functions by binding to glucocorticoid receptors, leading to the regulation of gene expression involved in inflammatory processes. The substance is typically formulated as a topical cream or ointment, allowing for localized treatment with minimal systemic absorption. Its chemical structure features a steroid backbone, which is common among corticosteroids, contributing to its biological activity. Clocortolone is generally well-tolerated, but like other corticosteroids, it may have side effects, particularly with prolonged use, including skin thinning and potential for systemic effects. As with any medication, it is essential to use clocortolone under the guidance of a healthcare professional to ensure appropriate application and to minimize risks.

Formula: C₂₂H₂₈ClFO₄

InChI: InChI=1S/C22H28ClFO4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-21(15,3)22(14,23)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1

InChI key: InChIKey=YMTMADLUXIRMGX-RFPWEZLHSA-N

SMILES: Cl[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@@H](C(CO)=O)[C@H](C)C3)[H])(C[C@H](F)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (6Alpha,11Beta,16Alpha)-9-Chloro-6-Fluoro-11,21-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (6Alpha,8Xi,10Xi,13Xi,14Xi,16Alpha,17Xi)-9-Chloro-6-Fluoro-11,21-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (6α,11β,16α)-9-Chloro-6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 9-Alpha-Chloro-6-Alpha-Fluoro-11-Beta,21-Dihydroxy-16-Alpha-Methylpregna-1,4-Diene-3,20-Dione
• 9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• 9-Chloro-6α-fluoro-11β,21-dihydroxy-17α-methylpregna-1,4-diene-3,20-dione
• 9-Chloro-6α-fluoro-16α-methyl-1,4-pregnadiene-11β,21-diol-3,20-dione
• Clorcortelone
• Pregna-1,4-diene-3,20-dione, 9-chloro-6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 9-chloro-6α-fluoro-11β,21-dihydroxy-16α-methyl-
• Clocortolone

Clocortolone (9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione)

CAS: 4828-27-7

Halogenated derivatives of adrenal cortical hormones

Formula: C₂₂H₂₈ClFO₄

Color and Shape: Off-White White Powder

Molecular weight: 410.16602

Ref: 45-1138493

Clocortolone

CAS: 4828-27-7

Clocortolone, a medium-strength corticosteroid, treats dermatitis as a cream ester called clocortolone pivalate.

Formula: C₂₂H₂₈ClFO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 410.91

Ref: TM-T21374

Clocortolone

CAS: 4828-27-7

Formula: C₂₂H₂₈ClFO₄

Color and Shape: White To Off-White Solid

Molecular weight: 410.92

Ref: 4Z-F-071006

Clocortolone

Controlled Product

CAS: 4828-27-7

Applications Corticosteroid used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.
References Rehm, K. et al.: Pharmaz. Zeit., 127, 888 (1982);

Formula: C₂₂H₂₈ClFO₄

Color and Shape: Neat

Molecular weight: 410.91

Ref: TR-C583800

Clocortolone-d3

Controlled Product

CAS: 4828-27-7

Applications Isotope labelled Corticosteroid (C583800) is used in the treatment of skin inflammation and other skin conditions arising for dermatoses.
References Rehm, K. et al.: Pharmaz. Zeit., 127, 888 (1982);

Formula: C₂₂D₃H₂₅ClFO₄

Color and Shape: Neat

Molecular weight: 413.925

Ref: TR-C583802

Clocortolone

Controlled Product

CAS: 4828-27-7

Clocortolone is a corticosteroid that binds to adrenergic receptors, leading to the inhibition of pro-inflammatory cytokines and leukotrienes. Clocortolone has been shown to be effective in the treatment of inflammatory diseases such as asthma, rheumatoid arthritis, or psoriasis. This drug can also be used in ophthalmic preparations because it is biocompatible and non-toxic. Clinical studies have shown that clocortolone is an efficacious anti-inflammatory agent in cancer therapy. Clocortolone has been repositioned as a drug for the treatment of chronic obstructive pulmonary disease (COPD) with high values of choroidal neovascularization

Formula: C₂₂H₂₈ClFO₄

Purity: Min. 95%

Molecular weight: 410.91 g/mol

Ref: 3D-FC20491