CAS 4829-46-3

(5alpha,6alpha)-3-methoxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6,14-diol

Description:

The chemical substance known as (5alpha,6alpha)-3-methoxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6,14-diol, with the CAS number 4829-46-3, is a synthetic opioid derivative. It is characterized by its complex morphinan structure, which includes a methoxy group and an epoxide functional group, contributing to its pharmacological properties. This compound exhibits analgesic effects and interacts with opioid receptors in the central nervous system, making it relevant in pain management and potential therapeutic applications. Its stereochemistry, particularly the 5alpha and 6alpha configurations, plays a crucial role in its biological activity and receptor binding affinity. Additionally, the presence of hydroxyl groups enhances its solubility and potential for metabolic transformations. As with many opioids, it may also have a risk of dependence and side effects, necessitating careful consideration in its use. Overall, this compound represents a significant area of interest in medicinal chemistry and pharmacology due to its structural features and biological implications.

Formula: C₁₈H₂₁NO₄

InChI: InChI=1/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-6,11,13,16,20-21H,7-9H2,1-2H3/t11-,13?,16-,17?,18?/m0/s1

SMILES: CN1CCC23c4c5ccc(c4O[C@H]2[C@H](C=CC3(C1C5)O)O)OC

7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α,14-diol (14-Hydroxycodeine)

Controlled Product

CAS: 4829-46-3

Formula: C₁₈H₂₁NO₄

Color and Shape: Neat

Molecular weight: 315.36

Ref: 86-MM0004.12

14-Hydroxycodeine

Controlled Product

CAS: 4829-46-3

Applications An impurity of Codeine (C634075), a weak narcotic analgesic.
References Eddy, S., et al.: J. Pharmacol. Exp. Ther., 67, 127 (1939), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 10, 93 (1981).

Formula: C₁₈H₂₁NO₄

Color and Shape: Neat

Molecular weight: 315.36

Ref: TR-H918415

14-Hydroxycodeine (1 mg/ml in Acetonitrile)

Controlled Product

CAS: 4829-46-3

Formula: C₁₈H₂₁NO₄

Color and Shape: Single Solution

Molecular weight: 315.36

Ref: TR-KIT5005

14-Hydroxycodeine-d3

Controlled Product

CAS: 4829-46-3

Formula: C₁₈D₃H₁₈NO₄

Color and Shape: Neat

Molecular weight: 318.382

Ref: TR-H918417

Codeine Impurity F

Controlled Product

CAS: 4829-46-3

Codeine Impurity F is a biochemical that is an impurity of codeine. Codeine Impurity F is a byproduct of the enzymatic reaction with morphine and the bacterial strain Pseudomonas putida. Codeine Impurity F has been shown to inhibit the growth of gram-negative bacteria, including Escherichia coli and Salmonella enterica, by binding to cellular membranes and inhibiting their function. It also binds to RNA in vitro and prevents translation of mRNA from its ribosome complex. The hydroxyl group on Codeine Impurity F binds to aluminium ions, which may interfere with the absorption of other drugs such as ampicillin or tetracycline. This impurity has been shown to have an effect on biological products such as immunoglobulins and albumin.

Formula: C₁₈H₂₁NO₄

Purity: Min. 95%

Molecular weight: 315.36 g/mol

Ref: 3D-FC161072