CAS 483-17-0

(-)-Cephaeline

Description:

(-)-Cephaeline is an alkaloid derived from the plant species Cephaelis ipecacuanha, commonly known for its use in traditional medicine. This compound is characterized by its complex structure, which includes a tetracyclic framework typical of many isoquinoline alkaloids. (-)-Cephaeline exhibits a range of biological activities, including antiemetic and expectorant properties, making it relevant in the treatment of conditions such as nausea and respiratory ailments. It is known to interact with various receptors in the body, influencing physiological responses. The substance is typically found in the form of a white to off-white crystalline powder and is soluble in organic solvents, but less so in water. Its stereochemistry is significant, as the (-) designation indicates its specific optical activity, which can affect its pharmacological effects. Due to its medicinal properties, (-)-Cephaeline has been studied for potential therapeutic applications, although its use is regulated in many regions due to safety concerns associated with its source and effects.

Formula: C₂₈H₃₈N₂O₄

InChI: InChI=1S/C28H38N2O4/c1-5-17-16-30-9-7-19-13-27(33-3)28(34-4)15-22(19)24(30)11-20(17)10-23-21-14-26(32-2)25(31)12-18(21)6-8-29-23/h12-15,17,20,23-24,29,31H,5-11,16H2,1-4H3/t17-,20-,23+,24-/m0/s1

InChI key: InChIKey=DTGZHCFJNDAHEN-OZEXIGSWSA-N

SMILES: C([C@H]1C[C@]2(C=3C(=CC(OC)=C(OC)C3)CCN2C[C@@H]1CC)[H])[C@@H]4C=5C(=CC(O)=C(OC)C5)CCN4

Synonyms:

• (1R)-1-[[(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-6-isoquinolinol
• (2Xi)-7',10,11-Trimethoxyemetan-6'-Ol
• 6-Isoquinolinol, 1-[[(2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-, (1R)-
• 7',10,11-Trimethoxyemetan-6'-Ol
• 7′,10,11-Trimethoxyemetan-6′-ol
• Cephalin (animal)
• Cepheline
• Desmethylemetine
• Dihydropsychotrine
• Emetan-6′-ol, 7′,10,11-trimethoxy-
• Cephaeline

Cephaeline

CAS: 483-17-0

Cephaeline

Purity: ≥95%

Molecular weight: 466.61g/mol

Ref: 54-BUP00683

Cephaeline

CAS: 483-17-0

Formula: C₂₈H₃₈N₂O₄

Molecular weight: 466.62

Ref: 7W-GY0679

Cephaeline

CAS: 483-17-0

Formula: C₂₈H₃₈N₂O₄

Purity: 95%~99%

Molecular weight: 466.622

Ref: BP-BP0330

Cephaeline

CAS: 483-17-0

Cephaeline: active on CLL cells (IC50: 35nM), inhibits HIF-1α, disrupts redox balance.

Formula: C₂₈H₃₈N₂O₄

Purity: 99.45% - 99.88%

Color and Shape: Solid

Molecular weight: 466.61

Ref: TM-TN1480

Cephaeline Hydrobromide

Controlled Product

CAS: 483-17-0

Stability Hygroscopic
Applications Hydrobromide Salt of Cephaeline (C256700), used as an emetic and expectorant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Crouch, D.J., et al.: J. Anal. Toxicol., 8, 63 (1984), Guengerich, F., et al.: Pharmacol. Ther., 54, 17 (1992), Myers, C., et al.: Environ. Toxicol. Chem., 13, 461 (1994),

Formula: C₂₈H₃₈N₂O₄·BrH

Purity: >90%

Color and Shape: Neat

Molecular weight: 547.52

Ref: TR-C256705

Cephaeline

Controlled Product

CAS: 483-17-0

Formula: C₂₈H₃₈N₂O₄

Color and Shape: Neat

Molecular weight: 466.61

Ref: TR-C256700

Cephaeline

CAS: 483-17-0

Cephaeline is an alkaloid compound, which is extracted from the roots of the ipecac plant, Psychotria ipecacuanha. It exhibits its primary mode of action by stimulating the chemoreceptor trigger zone in the brain, leading to a pronounced emetic effect. This mechanism activates the vomiting reflex, an action that also simultaneously stimulates bronchial secretions.

Purity: Min. 95%

Color and Shape: Yellow To Orange Solid

Molecular weight: 466.61

Ref: 3D-FC19891