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CAS 483-34-1

:

(-)-Tetrahydrocolumbamine

Description:
(-)-Tetrahydrocolumbamine is a naturally occurring alkaloid derived from various plant sources, particularly within the family of Ranunculaceae. It is characterized by its complex bicyclic structure, which includes a piperidine ring fused to a quinoline-like moiety. This compound exhibits a chiral center, leading to its designation as "(-)" indicating its specific optical rotation. (-)-Tetrahydrocolumbamine has garnered interest in pharmacology due to its potential biological activities, including anti-inflammatory and analgesic properties. It is also studied for its effects on the central nervous system, with some research suggesting it may influence neurotransmitter systems. The substance is typically isolated through extraction and purification processes from plant materials. Its solubility varies depending on the solvent used, and it is generally stable under standard laboratory conditions. As with many alkaloids, caution is advised when handling (-)-Tetrahydrocolumbamine due to its biological activity and potential toxicity at higher concentrations. Further research is ongoing to fully elucidate its mechanisms of action and therapeutic potential.
Formula:C20H23NO4
InChI:InChI=1S/C20H23NO4/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,9-10,16,22H,6-8,11H2,1-3H3/t16-/m0/s1
InChI key:InChIKey=KDFKJOFJHSVROC-INIZCTEOSA-N
SMILES:OC=1C=C2[C@]3(N(CC=4C(C3)=CC=C(OC)C4OC)CCC2=CC1OC)[H]
Synonyms:
  • 6H-Dibenzo[a,g]quinolizin-2-ol, 5,8,13,13a-tetrahydro-3,9,10-trimethoxy-, (S)-
  • Columbamine, tetrahydro-
  • 13aα-Berbin-2-ol, 3,9,10-trimethoxy-
  • 6H-Dibenzo[a,g]quinolizin-2-ol, 5,8,13,13a-tetrahydro-3,9,10-trimethoxy-, (13aS)-
  • Isocorypalmine
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