CAS 484-42-4: Angiotensin I
Description:Angiotensin I is a peptide hormone that plays a crucial role in the regulation of blood pressure and fluid balance in the body. It is a decapeptide, consisting of ten amino acids, and is derived from angiotensinogen, a precursor protein produced by the liver. Angiotensin I is biologically inactive but is converted into the active form, angiotensin II, by the action of the enzyme angiotensin-converting enzyme (ACE). This conversion is a key step in the renin-angiotensin system, which regulates blood pressure and electrolyte balance. Angiotensin I is characterized by its specific amino acid sequence, which includes proline and histidine residues, contributing to its structural properties. It is soluble in water and has a relatively short half-life in circulation, making it a transient component of the renin-angiotensin system. The study of angiotensin I and its derivatives is significant in pharmacology, particularly in the development of antihypertensive medications that target the renin-angiotensin system to manage conditions such as hypertension and heart failure.
Formula:C62H89N17O14
InChI:InChI=1/C62H89N17O14/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68)/t35-,41-,42-,43-,44-,45-,46-,47-,48-,50-,51-/m0/s1
- Synonyms:
- H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH
- L-alpha-aspartyl-N~5~-(diaminomethylidene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine
