CAS 484-43-5

(val5)-angiotensin I

Description:

(val5)-Angiotensin I, also known as Angiotensin I, is a peptide hormone that plays a crucial role in the regulation of blood pressure and fluid balance in the body. It is a decapeptide composed of ten amino acids, specifically derived from the precursor angiotensinogen, which is produced in the liver. The structure of (val5)-angiotensin I includes a sequence of amino acids that contribute to its biological activity, primarily through its interaction with angiotensin receptors. This peptide is a key component of the renin-angiotensin system, which is vital for cardiovascular homeostasis. Its primary function is to act as a substrate for the enzyme angiotensin-converting enzyme (ACE), which converts it into angiotensin II, a potent vasoconstrictor. The CAS number 484-43-5 uniquely identifies this substance in chemical databases, facilitating its study and application in pharmacology and medicine. Overall, (val5)-angiotensin I is significant in both physiological processes and therapeutic interventions related to hypertension and heart failure.

Formula: C₆₁H₈₇N₁₇O₁₄

InChI: InChI=1/C61H87N17O14/c1-32(2)22-40(62)51(82)71-43(25-37-28-65-30-68-37)53(84)74-45(24-35-12-8-7-9-13-35)59(90)78-21-11-15-47(78)56(87)72-44(26-38-29-66-31-69-38)55(86)77-50(34(5)6)58(89)73-42(23-36-16-18-39(79)19-17-36)54(85)76-49(33(3)4)57(88)70-41(14-10-20-67-61(63)64)52(83)75-46(60(91)92)27-48(80)81/h7-9,12-13,16-19,28-34,40-47,49-50,79H,10-11,14-15,20-27,62H2,1-6H3,(H,65,68)(H,66,69)(H,70,88)(H,71,82)(H,72,87)(H,73,89)(H,74,84)(H,75,83)(H,76,85)(H,77,86)(H,80,81)(H,91,92)(H4,63,64,67)/t40-,41-,42-,43-,44-,45-,46-,47-,49-,50-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1ccc(cc1)O)C(=N[C@@H](C(C)C)C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](CC(=O)O)C(=O)O)O)O)O)O)O)O)O)O)N

Synonyms:

• Angiotensin I, val(5)-
• 5-Val-angiotensin I
• Angiotensin I, valine(5)-
• Angiotensin I, 5-L-valine-
• L-leucyl-L-histidyl-L-phenylalanyl-L-prolyl-L-histidyl-L-valyl-L-tyrosyl-L-valyl-N~5~-(diaminomethylidene)-L-ornithyl-L-aspartic acid

[Val5]-Angiotensin I (Bovine)

CAS: 484-43-5

[Val5]-Angiotensin I (Bovine) is a peptide that activates angiotensin receptors. It is used as a research tool in the study of ion channels and protein interactions. The antibody recognizes the C-terminal region of angiotensin I, which can be used to inhibit the activation of these receptors by preventing binding to their ligands.

Formula: C₆₁H₈₇N₁₇O₁₄•CH₃COOH•5H₂O

Purity: Min. 95%

Molecular weight: 1,432.53 g/mol

Ref: 3D-PAN-4069-V

[Val5]-Angiotensin I (Bovine) (Bulk)

CAS: 484-43-5

Angiotensin I (Bovine) is a synthetic substrate that is used for the measurement of Angiotensin I-converting enzyme activity in vitro. It has been incubated with rat or bovine tissue and can be used as a chromatographic standard. This substrate binds to the active site of the enzyme and undergoes hydrolysis, which generates an increase in pH. The resulting product is then measured fluorimetrically by measuring the decrease in absorbance at 350 nm. This peptide has been found to have a pressor effect and an inhibitory effect on acid secretion.

Formula: C₆₁H₈₇N₁₇O₁₄•CH₃COOH•5H₂O

Purity: Min. 95%

Molecular weight: 1,432.53 g/mol

Ref: 3D-PAN-4069

(Val5)-Angiotensin I trifluoroacetate salt

CAS: 484-43-5

Angiotensin I is a peptide that belongs to the class of substances called angiotensins. This substance is found in many tissues and organs, including the brain, adrenal gland, and lung. Angiotensin I has been shown to be a pressor agent and also has biochemical effects on amino acid composition. The c-terminal sequence of this substance has been determined by incubating the molecule with pepsin at different pH values. The molecular weight of this substance is 938 Da and it has an amino acid composition of Asp-Arg-Val-Tyr-Val-His-Pro-Phe-His-Leu.

Formula: C₆₁H₈₇N₁₇O₁₄

Purity: Min. 95%

Molecular weight: 1,282.45 g/mol

Ref: 3D-FV110212