CAS 485-49-4: Bicuculline

Description: Bicuculline is a chemical compound classified as a selective antagonist of the GABA_A receptor, which plays a crucial role in inhibitory neurotransmission in the central nervous system. It is derived from the plant species *Corydalis*, and its structure features a benzylisoquinoline alkaloid framework. Bicuculline is known for its ability to block the effects of the neurotransmitter gamma-aminobutyric acid (GABA), leading to increased neuronal excitability. This property makes it a valuable tool in neuropharmacological research, particularly in studies investigating seizure activity and the mechanisms of epilepsy. The compound is typically used in laboratory settings and is not intended for therapeutic use in humans due to its potent effects on the nervous system. Bicuculline is usually administered in experimental models to explore its effects on synaptic transmission and to better understand the role of GABAergic signaling in various neurological conditions. Safety precautions are necessary when handling this substance, as it can induce convulsions and other neurological effects.

Formula: C₂₀H₁₇NO₆

InChI: InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1

InChI key: InChIKey=IYGYMKDQCDOMRE-ZWKOTPCHSA-N

SMILES: O=C1OC(C2=CC=C3OCOC3=C12)C4C5=CC=6OCOC6C=C5CCN4C

Synonyms:

• (5S)-6-methyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium
• (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one
• (6R)-6-[(5S)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one
• (R-(R*,S*))-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-furo(3,4-e)-1,3-benzodioxol-8(6H)-one
• 1,3-Dioxolo[4,5-g]isoquinoline, furo[3,4-e]-1,3-benzodioxol-8(6H)-one deriv.
• 6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[4,3-g][1,3]benzodioxol-8-one
• Bicuculina
• Bicucullin
• Bucuculline
• Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [R-(R*,S*)]-
• Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-
• Nsc 32192
• d-Bicuculline
• Bicuculline

(+)-Bicuculline

CAS: 485-49-4

• Formula: C₂₀H₁₇NO₆
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Yellow to Orange powder to crystal
• Molecular weight: 367.36

(+)-Bicuculline

CAS: 485-49-4

• Formula: C₂₀H₁₇NO₆
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 367.3520799999998

Bicuculline

CAS: 485-49-4

• Purity: ≥98%
• Molecular weight: 367.35g/mol

Bicuculline

CAS: 485-49-4

• Formula: C₂₀H₁₇NO₆
• Purity: 95%~99%
• Molecular weight: 367.357

(+)-Bicuculline

CAS: 485-49-4

• Formula: C₂₀H₁₇NO₆
• Molecular weight: 367.35

Bicuculline

CAS: 485-49-4

Bicuculline, a plant-derived GABAA receptor antagonist, identified in 1932, reacts to light.

• Formula: C₂₀H₁₇NO₆
• Purity: 98% - ≥98%
• Color and Shape: Light Yellow Powder
• Molecular weight: 367.35

(+)-bicuculline

CAS: 485-49-4

Natural alkaloid

• Formula: C₂₀H₁₇NO₆
• Purity: ≥ 98.0 % (HPLC)
• Color and Shape: Powder
• Molecular weight: 367.36

Bicuculline

CAS: 485-49-4

Applications Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity. References Curtis, et al.: …

• Formula: C₂₀H₁₇NO₆
• Color and Shape: Neat
• Molecular weight: 367.35

(+)-Bicuculline - Bio-X ™

CAS: 485-49-4

Bicuculline is a phthalide-isoquinoline compound and is a competitive GABA receptor antagonist. It blocks GABA’s …

• Formula: C₂₀H₁₇NO₆
• Purity: Min. 99 Area-%
• Color and Shape: Powder
• Molecular weight: 367.35 g/mol

(+)-Bicuculline

CAS: 485-49-4

Inhibitor of ionotropic receptor GABA(A)

• Formula: C₂₀H₁₇NO₆
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 367.35 g/mol

(+)-Bicuculline

CAS: 485-49-4

Please enquire for more information about (+)-Bicuculline including the price, delivery time and more detailed …

• Formula: C₂₀H₁₇NO₆
• Molecular weight: 367.36 g/mol